2-chloro-N-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | 934600-48-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 2-chloro-N-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• CAS: 934600-48-3
• 化学式: C₁₀H₁₁ClN₄
• 分子量: 222.677
• InChiKey: BYJZKZMTGMRTMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  53.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-chloro-N-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 在 N-氯代丁二酰亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 生成 2,5-dichloro-N-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  参考文献：
  名称：

  [EN] INHIBITORS OF PROTEIN KINASES
  [FR] INHIBITEURS DE PROTÉINES KINASES

  摘要：

  公开号：

  WO2009131687A3
• 作为产物：
  描述：

  环丁基胺 、 2,4-二氯-7H吡咯[2,3-D]嘧啶 在 N,N-二异丙基乙胺 作用下， 以 乙醇 为溶剂， 反应 0.33h， 生成 2-chloro-N-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  参考文献：
  名称：

  [EN] PYRROLOPYRIMIDINE COMPOUNDS, USE AS INHIBITORS OF THE KINASE LRRK2, AND METHODS FOR PREPARATION THEREOF
  [FR] COMPOSÉS DE PYRROLOPYRIMIDINE, LEUR UTILISATION À TITRE D'INHIBITEURS DE LA KINASE LRRK2, ET LEURS PROCÉDÉS DE PRÉPARATION

  摘要：

  本公开涉及某些吡咯吡嘧啶化合物，这些化合物能够抑制某些蛋白激酶，尤其是富含亮氨酸重复激酶2（LRRK2）蛋白。本公开的化合物可用于治疗由或与异常LRRK2激酶活性相关的多种疾病。本公开的化合物可用于治疗包括帕金森病在内的神经退行性疾病；癌前病变和癌症；自身免疫性疾病，如克罗恩病、类风湿关节炎和牛皮癣；以及麻风病（汉森病）。本摘要旨在作为特定领域搜索的扫描工具，并不旨在限制本发明。

  公开号：

  WO2017106771A1

文献信息

• Inhibitors of protein kinases
  申请人：Song Yonghong

  公开号：US20090298823A1

  公开（公告）日：2009-12-03

  The present invention is directed to compounds of formula I-II and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.

  本发明涉及化合物I-II的公式及其药学上可接受的盐，酯和前药，它们是syk和/或JAK激酶的抑制剂。本发明还涉及制造这种化合物所使用的中间体，制备这种化合物的方法，包含这种化合物的制药组合物，抑制syk和/或JAK激酶活性的方法，抑制血小板聚集的方法，以及预防或治疗由syk和/或JAK激酶活性至少部分介导的许多疾病，如不良血栓形成和非何杰金淋巴瘤的方法。
• INHIBITORS OF PROTEIN KINASES
  申请人：Song Yonghong

  公开号：US20130029944A1

  公开（公告）日：2013-01-31

  The present invention is directed to compounds of formula I-II and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.

  本发明涉及式I-II化合物及其药学上可接受的盐、酯和前药，这些化合物是syk和/或JAK激酶的抑制剂。本发明还涉及用于制备这些化合物的中间体、制备这种化合物的方法、含有这种化合物的药物组合物、抑制syk和/或JAK激酶活性的方法、抑制血小板聚集的方法以及预防或治疗由syk和/或JAK激酶活性至少部分介导的多种疾病，例如不良血栓形成和非何杰金淋巴瘤的方法。
• Pyrrolopyrimidine compounds, use as inhibitors of the kinase LRRK2, and methods for preparation thereof
  申请人：Southern Research Institute

  公开号：US10023579B2

  公开（公告）日：2018-07-17

  The present disclosure is concerned with certain pyrrolopyrimidine compounds that are capable of inhibiting certain protein kinases, and especially the leucine-rich repeat kinase 2 (LRRK2) protein. Compounds of the present disclosure can be used to treat a number of disorders caused by or associated with abnormal LRRK2 kinase activity. Compounds of the present disclosure can be used to treat disorders including neurodegenerative diseases such as Parkinson's disease; precancerous conditions and cancer; autoimmune disorders such as Crohn's disease, rheumatoid arthritis and psoriasis; and leprosy (Hansen's disease). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及某些吡咯并嘧啶化合物，它们能够抑制某些蛋白激酶，特别是富亮氨酸重复激酶2（LRRK2）蛋白。本公开的化合物可用于治疗由 LRRK2 激酶活性异常引起或与之相关的多种疾病。本公开内容的化合物可用于治疗包括神经退行性疾病（如帕金森病）、癌前病变和癌症、自身免疫性疾病（如克罗恩病、类风湿性关节炎和银屑病）以及麻风病（汉森氏病）在内的各种疾病。本摘要旨在作为在特定技术领域进行搜索的扫描工具，并非对本发明的限制。
• PYRROLOPYRIMIDINE COMPOUNDS, USE AS INHIBITORS OF THE KINASE LRRK2, AND METHODS FOR PREPARATION THEREOF
  申请人：Southern Research Institute

  公开号：US20170174694A1

  公开（公告）日：2017-06-22

  The present disclosure is concerned with certain pyrrolopyrimidine compounds that are capable of inhibiting certain protein kinases, and especially the leucine-rich repeat kinase 2 (LRRK2) protein. Compounds of the present disclosure can be used to treat a number of disorders caused by or associated with abnormal LRRK2 kinase activity. Compounds of the present disclosure can be used to treat disorders including neurodegenerative diseases such as Parkinson's disease; precancerous conditions and cancer; autoimmune disorders such as Crohn's disease, rheumatoid arthritis and psoriasis; and leprosy (Hansen's disease). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• US8258144B2
  申请人：——

  公开号：US8258144B2

  公开（公告）日：2012-09-04