[(3,4,7,8-tetramethyl-1,10-phenanthroline)2RuCl2]*3H2O | 68510-56-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: [(3,4,7,8-tetramethyl-1,10-phenanthroline)2RuCl2]*3H2O
• CAS: 68510-56-5
• 化学式: C₃₂H₃₂Cl₂N₄Ru*3H₂O
• 分子量: 698.655
• InChiKey: LVYUCGMPWXRKGV-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  1,2-联苯硫基乙烷 、 [(3,4,7,8-tetramethyl-1,10-phenanthroline)2RuCl2]*3H2O 以 乙醇 、 水 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  带有螯合硫醚配体的钌双二亚胺配合物：描绘1,10-菲咯啉基和2,2'-联吡啶基配体的取代作用

  摘要：

  尽管硫醚供体具有很高的π酸度，但钌（II）与双齿1,2-双（苯硫基）乙烷（dpte）配体和两个螯合二亚胺配体（即Ru （diimine）2（dpte）2+）形成络合物表现出源自最低MLCT激发态的室温流体溶液发射（二亚胺= 2,2'-联吡啶，5,5'-二甲基-2,2'-联吡啶4,4'-二叔丁基-丁基-2,2'-联吡啶，1,10-菲咯啉，5-甲基-1,10-菲咯啉，5-氯-1,10-菲咯啉，5-溴-1,10-菲咯啉，5-硝基- 1,10-菲咯啉，4,7-二苯基-1,10-菲咯啉和3,4,7,8-四甲基-1,10-菲咯啉）。晶体结构表明，该配合物形成了12种可能的构象/构型异构体中的2种，以及几何异构体的非统计分布。二亚胺配体与二苯基苯基之间还存在短的分子内π-π相互作用。光致溶剂分解产物[Ru（diimine）2（CH 3 CN）2 ]（PF 6）2，对于乙腈中的一种配合物，还通过单晶X射线

  DOI：

  10.1021/ic4022454
• 作为产物：
  描述：

  3,4,7,8-四甲基-1,10-菲罗啉 、 ruthenium(III) chloride trihydrate 在 lithium chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 [(3,4,7,8-tetramethyl-1,10-phenanthroline)2RuCl2]*3H2O
  参考文献：
  名称：

  带有螯合硫醚配体的钌双二亚胺配合物：描绘1,10-菲咯啉基和2,2'-联吡啶基配体的取代作用

  摘要：

  尽管硫醚供体具有很高的π酸度，但钌（II）与双齿1,2-双（苯硫基）乙烷（dpte）配体和两个螯合二亚胺配体（即Ru （diimine）2（dpte）2+）形成络合物表现出源自最低MLCT激发态的室温流体溶液发射（二亚胺= 2,2'-联吡啶，5,5'-二甲基-2,2'-联吡啶4,4'-二叔丁基-丁基-2,2'-联吡啶，1,10-菲咯啉，5-甲基-1,10-菲咯啉，5-氯-1,10-菲咯啉，5-溴-1,10-菲咯啉，5-硝基- 1,10-菲咯啉，4,7-二苯基-1,10-菲咯啉和3,4,7,8-四甲基-1,10-菲咯啉）。晶体结构表明，该配合物形成了12种可能的构象/构型异构体中的2种，以及几何异构体的非统计分布。二亚胺配体与二苯基苯基之间还存在短的分子内π-π相互作用。光致溶剂分解产物[Ru（diimine）2（CH 3 CN）2 ]（PF 6）2，对于乙腈中的一种配合物，还通过单晶X射线

  DOI：

  10.1021/ic4022454

文献信息

• In vivo Realization of Dual Photodynamic and Photothermal Therapy for Melanoma by Mitochondria Targeting Dinuclear Ruthenium Complexes under Civil Infrared Low‐power Laser
  作者：Meng‐Fan Wang、Rong Yang、Shi‐Jie Tang、Yu‐Ang Deng、Guo‐Kui Li、Dan Zhang、Daomei Chen、Xiaoxia Ren、Feng Gao

  DOI：10.1002/anie.202208721

  日期：2022.9.19

  Dinuclear ruthenium complexes with high two-photon absorption in the IR region and photothermal conversion efficiency have been developed to target mitochondria without penetrating the nucleus for tumor therapy. They show suppressed melanoma tumor growth in vitro and in vivo with dual two-photon photodynamic and photothermal therapy.

  已开发出在 IR 区域具有高双光子吸收和光热转换效率的双核钌配合物以靶向线粒体而无需穿透细胞核进行肿瘤治疗。他们通过双光子光动力和光热疗法在体外和体内显示抑制黑色素瘤肿瘤的生长。
• The synthesis and antibacterial activity study of ruthenium-based metallodrugs with a membrane-disruptive mechanism against <i>Staphylococcus aureus</i>
  作者：Yushou Chen、Lianghong Liu、Xuerong Wang、Zhouyuji Liao、Runbin Wang、Yanshi Xiong、Jianxin Cheng、Guijuan Jiang、Jintao Wang、Xiangwen Liao

  DOI：10.1039/d2dt01531e

  日期：——

  Ruthenium-based antibacterial agents with a membrane-disruptive mechanism were designed and synthesized. The complex Ru2 showed excellent antibacterial activity against S. aureus in vitro and in vivo.

  设计并合成了基于钌的膜破坏机制抗菌剂。Ru2复合物在体内外对金黄色葡萄球菌表现出优异的抗菌活性。
• 一种用于抑制隐球菌的吩嗪类钌（Ⅱ）配合物六氟磷酸盐及其制备方法和应用
  申请人：西南大学

  公开号：CN115583978A

  公开（公告）日：2023-01-10

  本发明公开了一种用于抑制隐球菌的吩嗪类钌(Ⅱ)配合物六氟磷酸盐及其制备方法和应用，本发明中的盐以钌金属离子为核心，以1,10‑菲啰啉或联吡啶及其衍生物为骨架配体，以DPPZ‑F,Cl、DPPZ‑Cl、DPPZ‑Me和BPPX为结合配体，其性质稳定，对新生隐球菌具有良好的抗菌活性。该盐可以和药学可以接受的载体或赋形剂混合制备成抗真菌药物。该盐合成步骤短，设备技术条件和工艺流程简单，原材料来源充裕，适合扩大化生产。
• Size-Selective Diffusion of Ferrocenes through Molecular Voids Created by Photolysis of Copolymeric Films
  作者：Sharon Gould、Kimberley H. Gray、Richard W. Linton、Thomas J. Meyer

  DOI：10.1021/j100043a053

  日期：1995.10

  Photolysis of the copolymeric films poly(x)[Ru(Me(1)bpy)(2)(vpy)(2)](PF6)(2x), (1 - X)[Ru(vbpy)(3)](PF6)(2-2x) formed by reductive electropolymerization on Pt electrodes (surface coverage Gamma = 2 x 10(-9) to 6 x 10(-9) mol/cm(2)) results in loss of the fragment -[-Ru(Me(4)bpy)(2)](PF6)(2). For x = 0.4-0.6 electrochemical and angle-resolved XPS measurements before and after photolysis show that film thickness is unaffected by photolysis. Diffusion of ferrocene and substituted ferrocenes through the films was studied by rotated disk voltammetry, from which values for PDs,pol were derived. D-s,D-pol is the diffusion coefficient of ferrocene through the film, and P is the partition coefficient within the film. Removal of -[-Ru(Me(4)bpy)(2)](PF6)(2) by photolysis creates molecular sized voids and increases PDs,pol by factors of 10-20. The photolyzed films act as size-selective membranes with PDs,pol, decreasing by as much as 16 as the volume of the ferrocene increases from 150 to 500 Angstrom(3). The diffusional properties of the films can be varied somewhat by adding substituents to the bpy rings of the leaving group or by partly filling the molecular voids by coordination to pyridyl groups released in the photolysis step.
• Bithiophene‐Functionalized Infrared Two‐Photon Absorption Metal Complexes as Single‐Molecule Platforms for Synergistic Photodynamic, Photothermal, and Chemotherapy
  作者：Xue‐Lian Li、Meng‐Fan Wang、Li‐Zhen Zeng、Guo‐Kui Li、Run‐Yu Zhao、Fu‐Dan Liu、Yun Li、Yu‐Fei Yan、Qishuai Liu、Zhao Li、Hongbin Zhang、Xiaoxia Ren、Feng Gao

  DOI：10.1002/anie.202402028

  日期：2024.7

  A planar conjugated ligand functionalized with bithiophene and its Ru(II), Os(II), and Ir(III) complexes have been constructed as single‐molecule platform for synergistic photodynamic, photothermal, and chemotherapy. The complexes have significant two‐photon absorption at 808 nm and remarkable singlet oxygen and superoxide anion production in aqueous solution and cells when exposed to 808 nm infrared irradiation. The most potent Ru(II) complex Ru7 enters tumor cells via the rare macropinocytosis, locates in both nuclei and mitochondria, and regulates DNA‐related chemotherapeutic mechanisms intranuclearly including DNA topoisomerase and RNA polymerase inhibition and their synergistic effects with photoactivated apoptosis, ferroptosis and DNA cleavage. Ru7 exhibits high efficacy in vivo for malignant melanoma and cisplatin‐resistant non‐small cell lung cancer tumors, with a 100% survival rate of mice, low toxicity to normal cells and low residual rate. Such an infrared two‐photon activatable metal complex may contribute to a new generation of single‐molecule‐based integrated diagnosis and treatment platform to address drug resistance in clinical practice and phototherapy for large, deeply located solid tumors.