5-methyl-thiophene-2-carboxylic acid [5-(3-fluoro-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide | 492469-36-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-methyl-thiophene-2-carboxylic acid [5-(3-fluoro-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide
• 英文别名: N-[5-(3-fluorophenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-5-methylthiophene-2-carboxamide
• CAS: 492469-36-0
• 化学式: C₁₉H₁₅FN₄O₂S
• 分子量: 382.418
• InChiKey: SKAAOGJUJIKDJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  96.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• 8-METHOXY-(1,2,4)TRIAZOLO(1,5-A)PYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1412352A1

  公开（公告）日：2004-04-28
• US6514989B1
  申请人：——

  公开号：US6514989B1

  公开（公告）日：2003-02-04
• [EN] 8-METHOXY-(1,2,4)TRIAZOLO(1,5-A)PYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS<br/>[FR] DERIVES DE 8-METHOXY-(1,2,4)TRIAZOLO(1,5-A)PYRIDINE ET UTILISATIONS DE CEUX-CI SOUS LA FORME DE LIGANDS DE RECEPTEUR D'ADENOSINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2003010167A1

  公开（公告）日：2003-02-06

  The invention relates to a compound of the general formula (I) wherein R1 is phenyl or thiophenyl, wherein the rings may be unsubstitued or substituded by one or two substituents, selected from the groups, consisting of halogen, trifluoromethyl, lower alkyl, lower alkoxy, acetylamino, acetyl, lower alkenyl, -C(O)O-lower alkyl or thio-lower alkyl; R2 is phenyl or thiophenyl, wherein the rings may be unsubstituted or substituted by one or two substituents, selected from the groups consisting of halogen, lower alkyl, halogen-lower alkyl or lower alkoxy; and their pharmaceutically acceptable salts. These compounds have a good affinity to the adenosine receptor and they can therefore be used for the treatment of diseases, related to this receptor.