1-Pyrrolidin-1-yl-propan-2-thiol | 1194-07-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-Pyrrolidin-1-yl-propan-2-thiol
• 英文别名: 1-pyrrolidin-1-yl-propane-2-thiol；1-Pyrrolidin-1-ylpropane-2-thiol
• CAS: 1194-07-6
• 化学式: C₇H₁₅NS
• 分子量: 145.269
• InChiKey: GDXBIRHWUUZXPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  4.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
  申请人：Amgen Inc.

  公开号：US20210009577A1

  公开（公告）日：2021-01-14

  Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

  本文提供KRAS G12C抑制剂，其组成，以及使用方法。这些抑制剂对于治疗多种疾病有用，包括胰腺癌，结直肠癌和肺癌。
• CXCR3 RECEPTOR AGONISTS
  申请人：CELGENE INTERNATIONAL II SARL

  公开号：US20190345133A1

  公开（公告）日：2019-11-14

  Compounds are provided having the structure of the following Formula I: where R, R 1 , R 2 , R 3 a and R 3b are as defined herein. Pharmaceutical compositions comprising such compounds, as well as methods related to their manufacture and use, are also provided.