(S)-4-(2-carboxymethoxy-5-chloro-phenyl)-2-methyl-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid benzyl ester | 1531634-68-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-4-(2-carboxymethoxy-5-chloro-phenyl)-2-methyl-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid benzyl ester
• 英文别名: 2-[4-chloro-2-[(4S)-2-methyl-5-phenylmethoxycarbonyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-4-yl]phenoxy]acetic acid
• CAS: 1531634-68-0
• 化学式: C₂₃H₂₁ClN₂O₅S
• 分子量: 472.949
• InChiKey: SCFZYCGPCUTVMS-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  117
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：US20150158883A1

  公开（公告）日：2015-06-11

  The present invention relates to 1-phenyl-substituted heterocyclyl derivatives of the formula (I), wherein Y, Z, R 1 , R 2 , R 3 and R 4 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D 2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.

  本发明涉及式(I)的1-苯基取代的杂环基衍生物，其中Y、Z、R1、R2、R3和R4如描述中所述，并且它们作为前列腺素受体调节剂的用途，尤其是前列腺素D2受体调节剂，在治疗各种前列腺素介导的疾病和障碍中使用，以及包含这些化合物的制药组合物和其制备方法。
• US9169270B2
  申请人：——

  公开号：US9169270B2

  公开（公告）日：2015-10-27