isopropyl 2-cyclohexyl-1-{[(4-methoxybenzyl)amino]carbonyl}-5-methyl-3-oxoisoindoline-4-carboxylate | 1256358-20-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: isopropyl 2-cyclohexyl-1-{[(4-methoxybenzyl)amino]carbonyl}-5-methyl-3-oxoisoindoline-4-carboxylate
• CAS: 1256358-20-9
• 化学式: C₂₈H₃₄N₂O₅
• 分子量: 478.588
• InChiKey: OIXFUMLNMIVPID-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以29%的产率得到isopropyl 2-cyclohexyl-1-{[(4-methoxybenzyl)amino]carbonyl}-5-methyl-3-oxoisoindoline-4-carboxylate
  参考文献：
  名称：

  Thiophene-containing products of the Ugi reaction in an oxidation-triggered IMDA/aromatization cascade: a simple access to 3-oxoisoindolines

  摘要：

  A novel approach to skeletally diverse 3-oxoisoindolines has been developed which includes preparation of Ugi adducts containing thiophene and fumaric acid residues. When treated with excess m-CPBA at room temperature, these precursors undergo a simple oxidative cycloaddition/aromatization transformation and the corresponding 3-oxoisoindoline products are isolated in fair chemical yield over two steps. The second step is thought to include S-oxidation/IMDA/S-oxidation/SO2 extrusion/aromatization events. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.07.135