1-[4-[2-(Cyclohexylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol | 63659-40-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1-[4-[2-(Cyclohexylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol
• CAS: 63659-40-5
• 化学式: C₂₁H₃₅NO₃
• 分子量: 349.514
• InChiKey: XAQUXKYKUDRDHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  25
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  50.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  环己基甲基4-甲基苯磺酸盐 在 palladium on activated charcoal sodium hydroxide 、 氢气 、 sodium hydride 作用下， 以 四氢呋喃 、 水 为溶剂， 25.0~60.0 ℃ 、344.73 kPa 条件下， 反应 78.0h， 生成 1-[4-[2-(Cyclohexylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol
  参考文献：
  名称：

  Synthesis of a series of compounds related to betaxolol, a new .beta.1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases

  摘要：

  A series of para-substituted phenoxypropanolamines has been synthesized and tested for beta-adrenoceptor blocking activity. Some derivatives (8, 11, 12, 20, 21) exhibited greater in vitro potency than the reference drugs metoprolol and propranolol. This series, in contrast to propranolol but similar to metoprolol, possesses cardioselectivity. The 3-[p-[(cycloalkylmethoxy)ethyl]phenoxy]-1-substituted-amino-2-prop anol derivatives 8 (cyclopropylmethoxyethyl: betaxolol) and 11 (cyclobutylmethoxyethyl) produced antihypertensive effects in spontaneously hypertensive rats. Betaxolol (Kerlon, 8) was found to exhibit an appropriate preclinical pharmacological and human pharmacokinetic profile (elevated oral bioavailability and prolonged plasma half-life) for the treatment of chronic cardiovascular diseases such as hypertension and angina.

  DOI：

  10.1021/jm00389a008

文献信息

• US4252984A
  申请人：——

  公开号：US4252984A

  公开（公告）日：1981-02-24
• US4311708A
  申请人：——

  公开号：US4311708A

  公开（公告）日：1982-01-19
• Synthesis of a series of compounds related to betaxolol, a new .beta.1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases
  作者：Philippe M. Manoury、Jean L. Binet、Jean Rousseau、Francoise M. Lefevre-Borg、Icilio G. Cavero

  DOI：10.1021/jm00389a008

  日期：1987.6

  A series of para-substituted phenoxypropanolamines has been synthesized and tested for beta-adrenoceptor blocking activity. Some derivatives (8, 11, 12, 20, 21) exhibited greater in vitro potency than the reference drugs metoprolol and propranolol. This series, in contrast to propranolol but similar to metoprolol, possesses cardioselectivity. The 3-[p-[(cycloalkylmethoxy)ethyl]phenoxy]-1-substituted-amino-2-prop anol derivatives 8 (cyclopropylmethoxyethyl: betaxolol) and 11 (cyclobutylmethoxyethyl) produced antihypertensive effects in spontaneously hypertensive rats. Betaxolol (Kerlon, 8) was found to exhibit an appropriate preclinical pharmacological and human pharmacokinetic profile (elevated oral bioavailability and prolonged plasma half-life) for the treatment of chronic cardiovascular diseases such as hypertension and angina.