4-乙基-1-碘-2-甲基苯 | 866996-02-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-乙基-1-碘-2-甲基苯
• 英文名称: 4-ethyl-1-iodo-2-methyl-benzene
• 英文别名: 4-Aethyl-1-jod-2-methyl-benzol；4-Ethyl-1-iodo-2-methylbenzene
• CAS: 866996-02-3
• 化学式: C₉H₁₁I
• 分子量: 246.091
• InChiKey: HNFFMNJLZFMPAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  4-乙基-1-碘-2-甲基苯 在 铬酸 作用下， 生成 1-(2-异丙基苯基)-2-硫脲
  参考文献：
  名称：

  Willgerodt; Jahn, Justus Liebigs Annalen der Chemie, 1911, vol. 385, p. 328

  摘要：

  DOI：
• 作为产物：
  描述：

  4-ethyl-2-methylaniline 生成 4-乙基-1-碘-2-甲基苯
  参考文献：
  名称：

  Willgerodt; Jahn, Justus Liebigs Annalen der Chemie, 1911, vol. 385, p. 328

  摘要：

  DOI：

文献信息

• Green electroluminescent compounds and organic electroluminescent device using the same
  申请人：Gracel Display Inc.

  公开号：EP2067766A1

  公开（公告）日：2009-06-10

  The present invention relates to novel organic electroluminescent compounds, organic electroluminescent devices and organic solar cells comprising the same. Specifically, the organic electroluminescent compounds according to the invention are represented by Chemical Formula (1) : wherein, R1 and R2 independently represent hydrogen, deuterium, linear or branched (C1-C20)alkyl, (C2-C20)alkenyl, (C2-C20)alkynyl, (C3-C15)cycloalkyl, tri(C1-C20)alkylsilyl, di(C1-C20)alkyl(C6-C20)arylsilyl, tri(C6-C20)arylsilyl, adamantyl, (C7-C15)bicycloalkyl or (C4-C20)heteroaryl, and the alkyl, alkenyl, alkynyl, cycloalkyl, trialkylsilyl, dialkylarylsilyl, triarylsilyl, adamantyl, bicycloalkyl or heteroaryl of R1 and R2 may be further substituted by one or more substituent(s) selected from deuterium, linear or branched (C1-C20)alkyl, (Cl-C20)alkenyl, (C1-C20)alkynyl, halogen, phenyl, fluorenyl, naphthyl and anthryl. The electroluminescent compounds according to the present invention are green electroluminescent compounds, of which the luminous efficiency and device lifetime have been maximized.

  本发明涉及新型有机电致发光化合物、含有该化合物的有机电致发光器件和有机太阳能电池。具体地，根据本发明的有机电致发光化合物由化学式（1）表示：其中，R1和R2独立地表示氢、氘、直链或支链（C1-C20）烷基、（C2-C20）烯基、（C2-C20）炔基、（C3-C15）环烷基、三（C1-C20）烷基硅基、二（C1-C20）烷基（C6-C20）芳基硅基、三（C6-C20）芳基硅基、金刚烷基、（C7-C15）双环烷基或（C4-C20）杂环芳基，而R1和R2的烷基、烯基、炔基、环烷基、三烷基硅基、二烷基芳基硅基、三芳基硅基、金刚烷基、双环烷基或杂环芳基可能进一步由氘、直链或支链（C1-C20）烷基、（Cl-C20）烯基、（C1-C20）炔基、卤素、苯基、芴基、萘基和蒽基中选择的一个或多个取代基所取代。根据本发明的电致发光化合物是绿色电致发光化合物，其发光效率和器件寿命已经最大化。
• NOVEL COMPOUNDS
  申请人：Bennett Nicholas J.

  公开号：US20130045955A1

  公开（公告）日：2013-02-21

  The present invention provides compounds of formula (I) herein R 1 , R 2 , R 3 and R 4 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明提供了公式（I）的化合物，其中R1、R2、R3和R4如规范中所定义，并且其药学上可接受的盐，以及它们的制备方法，含有它们的制药组合物和它们在治疗中的使用。
• Novel Compounds
  申请人：BENNETT Nicholas J.

  公开号：US20090209524A1

  公开（公告）日：2009-08-20

  The present invention provides compounds of formula (1) wherein R 1 , R 2 , R 3 and R 4 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明提供了式（1）的化合物 其中R1、R2、R3和R4如规范中所定义，并且其药学上可接受的盐，以及制备它们的方法，含有它们的制药组合物以及它们在治疗中的使用。
• HISTONE ACETYLASE P300 INHIBITOR AND USE THEREOF
  申请人：Hinova Pharmaceuticals Inc.

  公开号：EP3889138A1

  公开（公告）日：2021-10-06

  Provided are a histone acetylase p300 inhibitor and a use thereof, belonging to the filed of medicinal chemistry technology. A compound represented by formula (I), or a stereochemical isomer thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, can inhibit the activity of histone acetylase p300 and inhibit the proliferation activity of a variety of tumor cells.

  本发明提供了一种组蛋白乙酰化酶p300抑制剂及其用途，属于药物化学技术领域。一种由式（I）代表的化合物，或其立体化学异构体，或其溶液，或其药学上可接受的盐，可以抑制组蛋白乙酰化酶 p300 的活性，抑制多种肿瘤细胞的增殖活性。
• Modulators of ATP-binding cassette transporters
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US10626111B2

  公开（公告）日：2020-04-21

  Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

  本发明的化合物及其药学上可接受的组合物可用作 ATP 结合盒（"ABC"）转运体或其片段（包括囊性纤维化跨膜传导调节剂（"CFTC"））的调节剂。本发明还涉及使用本发明化合物治疗 ABC 转运体介导的疾病的方法。