(o-Carboxybenzyl)-diphenylphosphin | 59807-68-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (o-Carboxybenzyl)-diphenylphosphin
• 英文别名: 2-(Diphenylphosphanylmethyl)benzoic acid
• CAS: 59807-68-0
• 化学式: C₂₀H₁₇O₂P
• 分子量: 320.328
• InChiKey: BLDUTSMPOUIRHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Chemoselective ligation
  申请人：——

  公开号：US20020016003A1

  公开（公告）日：2002-02-07

  The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

  本发明具有一种可以在生理条件下进行的化学选择性连接反应。一般来说，该发明涉及特别设计的膦的缩合，可以在两个反应物之间形成酰胺键，从而生成一个包含膦基团的最终产物，或者可以设计成包含可切割的连接剂，以便将膦的取代基转移到叠氮基上，释放氧化膦副产物，并在最终产物中产生一个天然酰胺键。该反应的选择性及其与水性环境的兼容性使其可以应用于体内（例如，在细胞表面或细胞内）和体外（例如，合成肽和其他聚合物，生产改性（例如，标记的）氨基酸）。
• CHEMOSELECTIVE LIGATION
  申请人：Saxon Eliana

  公开号：US20080214801A1

  公开（公告）日：2008-09-04

  The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

  本发明涉及一种可在生理条件下进行的化学选择性连接反应。一般而言，该发明涉及特别设计的膦化合物的缩合反应，该膦化合物可以提供在两个反应物之间形成酰胺键的反应，从而产生包含膦基团的最终产物，或者可以被设计成包含可切断的连接剂，以便将膦的取代基转移到偶氮化物上，释放氧化的膦副产物并在最终产物中产生天然的酰胺键。该反应的选择性及其与水环境的兼容性使其适用于体内应用（例如，在细胞表面或细胞内）和体外应用（例如，合成肽和其他聚合物，生产修饰（例如，标记）的氨基酸）。
• CHEMOSELECTIVE LIGATION
  申请人：Saxon Eliana

  公开号：US20110236930A1

  公开（公告）日：2011-09-29

  The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

  本发明涉及一种可以在生理条件下进行的化学选择性连接反应。一般来说，本发明涉及特别设计的膦化合物的缩合，该膦化合物可以提供在两个反应物之间形成酰胺键，从而产生包含膦基团的最终产物，或者可以被设计为包含可断裂的连接器，以便将膦的取代基转移到偶氮化物上，释放出氧化的膦副产物并在最终产物中产生天然的酰胺键。该反应的选择性及其与水相环境的兼容性使其适用于体内（例如，细胞表面或细胞内）和体外（例如，合成肽和其他聚合物，生产修饰的（例如，标记的）氨基酸）。
• CHEMOSELECTIVE LIGATION BY USE OF A PHOSPHINE
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：EP1263771A2

  公开（公告）日：2002-12-11
• US6180831B1
  申请人：——

  公开号：US6180831B1

  公开（公告）日：2001-01-30