(3aR,3a'R,4S,4'S,7R,7aS,7'R,7a'S)-2,2'-((tri-m-tolyl-l5-stibanediyl)bis(oxy))bis(3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione) | 712342-81-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: (3aR,3a'R,4S,4'S,7R,7aS,7'R,7a'S)-2,2'-((tri-m-tolyl-l5-stibanediyl)bis(oxy))bis(3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione)
• CAS: 712342-81-9
• 化学式: C₃₇H₃₃N₂O₈Sb
• 分子量: 755.428
• InChiKey: ATFGINBZULDRHW-RLUBZRAXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.77
• 重原子数：
  48.0
• 可旋转键数：
  7.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  111.68
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  tris-(m-tolyl)antimony(V) dibromide 、 N-hydroxy-3,6-epoxy-1,2,3,6-tetrahydrophthalimide 在 Et₃N 作用下， 以 四氢呋喃 为溶剂， 以58.3%的产率得到(3aR,3a'R,4S,4'S,7R,7aS,7'R,7a'S)-2,2'-((tri-m-tolyl-l5-stibanediyl)bis(oxy))bis(3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione)
  参考文献：
  名称：

  Synthesis, crystal structures and in vitro antitumor activities of some arylantimony derivatives of analogues of demethylcantharimide

  摘要：

  A series of novel aylantimony derivatives of analogues of demethylcantharimide with the formulae ArnSbL(5-n) and ArnSbL'((5-n))(LH = N-hydroxy-demethyldehydrogencantharimide, L'H = N-hydroxy-demethyleantharimide, n = 3, 4; Ar=C6H5, 4CH(3)C(6)H(4), 3-CH3C6H4, 2-CH3C6H4, 4-ClC6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR, 1 H NMR and mass spectroscopy. The crystal structures of (C6H5)(4)SbL, (4-CH3C6H4)(3)SbL2 and (3-CHC6H4)(3)SbL'(2) were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against six cancer cells are reported. (C) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2004.02.015