4-[(1S)-2-amino-1-hydroxypropyl]phenol | 552-85-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(1S)-2-amino-1-hydroxypropyl]phenol
• CAS: 552-85-2；771-91-5；1926-72-3；13104-32-0；37692-93-6；52446-53-4；62928-85-2；62928-86-3；73027-12-0
• 化学式: C₉H₁₃NO₂
• 分子量: 167.208
• InChiKey: JAYBQRKXEFDRER-IOJJLOCKSA-N

物化性质

• 沸点：
  357.9±27.0 °C(Predicted)
• 密度：
  1.198±0.06 g/cm3(Predicted)
• 溶解度：
  酸水溶液（微溶）、甲醇（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2922509090

文献信息

• AMINO ALCOHOL DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USE OF THESE
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：EP1679304A1

  公开（公告）日：2006-07-12

  The present invention provides compounds represented by general formula (I): a prodrug thereof, or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; each of R2 and R3 is independently hydrogen or lower alkyl; each of R4, R5 and R6 is independently hydrogen, halogen, lower alkyl or lower alkoxy; R7 is hydrogen or lower alkyl; R8 is hydrogen, halogen, lower alkyl, lower alkoxy, etc; R9 is -COR10, -A1-COR10, -O-A2-COR10, etc; Ar is optionally substituted phenyl or heteroaryl; and A is a bond, -OCH2-, etc, which exhibit potent and selective β3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

  本发明提供了由通式（I）表示的化合物： 其前药，或其药用可接受的盐，其中R1是氢或较低的烷基；R2和R3中的每一个独立地是氢或较低的烷基；R4、R5和R6中的每一个独立地是氢、卤素、较低的烷基或较低的烷氧基；R7是氢或较低的烷基；R8是氢、卤素、较低的烷基、较低的烷氧基等；R9是-COR10、-A1-COR10、-O-A2-COR10等；Ar是可选择地取代的苯基或杂环芳基；A是键，-OCH2-等，具有强效和选择性的β3-肾上腺素受体刺激活性。本发明还提供了含有所述化合物的药物组合物，以及其用途。
• Synthesis of phenoxyacetic acid derivatives
  申请人：Winter Eric

  公开号：US20070088174A1

  公开（公告）日：2007-04-19

  The present invention relates to an improved process for the preparation of substituted 2-(4-carbonylmethoxy-optionally 2,5-disubstituted-phenyl)-acetaldehydes, in particular 2-(4-alkoxycarbonylmethoxy-optionally 2,5-disubstituted-phenyl)-acetaldehydes and their use in the synthesis of optionally substituted 2-[4-[2-[[-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-amino]ethyl]-optionally 2,5-disubstituted-phenoxy]acetic acid derivatives or the salts thereof, which may be used as pharmaceutically active substances.

  本发明涉及一种改进的方法，用于制备取代的2-(4-羰基甲氧基-可选地2,5-二取代苯基)-乙醛，特别是2-(4-烷氧羰基甲氧基-可选地2,5-二取代苯基)-乙醛及其在合成可选地取代的2-[4-[2-[[-2-羟基-2-(4-羟基苯基)-1-甲基乙基]-氨基]乙基]-可选地2,5-二取代苯氧基]乙酸衍生物或其盐中的用途，这些衍生物可用作药用活性物质。
• [EN] HOMOARGININE PRODRUGS AND/OR CONJUGATES OF AMPHETAMINE AND OTHER STIMULANTS AND PROCESSES FOR MAKING AND USING THE SAME<br/>[FR] PROMÉDICAMENTS DE L'HOMOARGININE ET/OU CONJUGUÉS D'AMPHÉTAMINES ET D'AUTRES STIMULANTS ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：KEMPHARM INC

  公开号：WO2013019187A1

  公开（公告）日：2013-02-07

  Disclosed are homoarginine amphetamine prodrug and/or conjugate compositions, salts thereof, or a combination thereof that can reduce or prevent amphetamine side effects in a human subject, and methods to reduce or prevent amphetamine side effects in a human subject.

  本文披露了一种同型精氨酸苯丙胺前药和/或结合物组合物，其盐或二者的组合物可以减少或预防人体主体中苯丙胺的副作用，并提供了减少或预防人体主体中苯丙胺副作用的方法。
• HOMOARGININE PRODRUGS AND/OR CONJUGATES OF AMPHETAMINE AND OTHER STIMULANTS AND PROCESSES FOR MAKING AND USING THE SAME
  申请人：Mickle Travis

  公开号：US20140171510A1

  公开（公告）日：2014-06-19

  Disclosed are homoarginine amphetamine prodrug and/or conjugate compositions, salts thereof, or a combination thereof that can reduce or prevent amphetamine side effects in a human subject, and methods to reduce or prevent amphetamine side effects in a human subject.

  本文公开了一种同型精氨酸苯丙胺前药和/或结合物组合物，其盐或二者的组合，可以减少或预防人体主体中苯丙胺的副作用，并且提供了减少或预防人体主体中苯丙胺副作用的方法。
• Process for producing optically active beta-amino alcohol
  申请人：Nishiyama Akira

  公开号：US20050277791A1

  公开（公告）日：2005-12-15

  A process for easily producing an optically active β-amino alcohol useful as a pharmaceutical intermediate from an inexpensive, readily available starting material is provided. A readily available α-substituted ketone is reacted with an optically active amine to yield a diastereomer mixture of an optically active α-substituted aminoketone. One of the diastereomers is isolated optionally after the diastereomers are converted to salts with an acid. The optically active α-substituted aminoketone or a salt thereof thus isolated was stereoselectively reduced to yield an optically active β-substituted amino alcohol. The optically active β-substituted amino alcohol is subjected to hydrogenolysis to produce an optically active β-amino alcohol or a salt thereof.

  提供了一种从廉价、易得的起始材料中轻松生产有用于制药中间体的光学活性β-氨基醇的方法。将易得的α-取代酮与光学活性胺反应，得到光学活性α-取代氨基酮的对映体混合物。在对映体混合物与酸转化为盐之后，可以选择性地分离其中一种对映体。分离出的光学活性α-取代氨基酮或其盐经立体选择性还原，得到光学活性β-取代氨基醇。将光学活性β-取代氨基醇进行氢解反应，得到光学活性β-氨基醇或其盐。