5β-cholan-12α-ol | 35649-45-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 5β-cholan-12α-ol
• 英文别名: 12α-Hydroxy-5β-cholan
• CAS: 35649-45-7
• 化学式: C₂₄H₄₂O
• 分子量: 346.597
• InChiKey: XDIPKRJNVQCAIX-YHWIQFDSSA-N

物化性质

• 沸点：
  428.4±13.0 °C(Predicted)
• 密度：
  0.972±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.44
• 重原子数：
  25.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  5β-cholan-12α-ol 在 chromium(VI) oxide 、 lithium aluminium tetrahydride 、 溶剂黄146 、 sodium nitrite 作用下， 以 乙醚 为溶剂， 生成
  参考文献：
  名称：

  Ahmed,S. et al., Australian Journal of Chemistry, 1971, vol. 24, p. 521 - 547

  摘要：

  DOI：
• 作为产物：
  描述：

  12α,24-dihydroxy-5β-cholane 生成 5β-cholan-12α-ol
  参考文献：
  名称：

  Ahmed,S. et al., Australian Journal of Chemistry, 1971, vol. 24, p. 521 - 547

  摘要：

  DOI：

文献信息

• Empirical and theoretical evidence for herd size as a risk factor for swine diseases
  作者：Ian A. Gardner、Preben Willeberg、Jan Mousing

  DOI：10.1079/ahrr200239

  日期：2002.6

  Herd size is frequently studied as a risk factor for swine diseases, yet the biological rationale for a reported association with herd size (whether positive or negative) is rarely adequately discussed in published epidemiological studies. Biologically plausible reasons for a positive association between herd size and disease include a greater risk of introduction of pathogens from outside the herd, greater risk of transmission of pathogens within and among herds when the herd is large, and effects of management and environmental factors that are related to herd size. However, compared with owners of small herds, owners of large herds might more frequently adopt management and housing practices that mitigate this theoretically increased risk. We used studies of pleuritis, pneumonia and pseudorabies to describe the epidemiological issues involved in evaluations of the relationship between management factors, herd size and disease. In future studies, we recommend that (i) herd size be measured in a way that best characterizes the true population at risk; (ii) studies that evaluate management-related risk factors should account for herd size wherever possible; (iii) population-based studies of the interrelationships among management factors and between management factors, herd size, herd density and pig density be done; (iv) likely biological reasons for any herd-size effect be postulated; and (v) the distribution of herd sizes in the source population and the study sample be described.

  摘要 猪群规模作为猪病的一个风险因素经常被研究，但在已发表的流行病学研究中，很少充分讨论所报告的猪群规模与疾病相关的生物学原理（无论是正相关还是负相关）。从生物学角度看，猪群规模与疾病呈正相关的合理原因包括：从猪群外部引入病原体的风险更大；猪群规模大时，病原体在猪群内部和猪群之间传播的风险更大；以及与猪群规模相关的管理和环境因素的影响。然而，与小规模牛群的所有者相比，大规模牛群的所有者可能会更频繁地采取管理和饲养措施来降低理论上增加的风险。我们通过对胸膜炎、肺炎和伪狂犬病的研究，描述了在评估管理因素、牛群规模和疾病之间的关系时所涉及的流行病学问题。在今后的研究中，我们建议：(i) 对牛群规模的测量应能最好地描述真正的风险种群；(ii) 评估与管理相关的风险因素的研究应尽可能考虑牛群规模；(iii) 对管理因素之间以及管理因素、牛群规模、牛群密度和猪密度之间的相互关系进行基于种群的研究；(iv) 假设任何牛群规模效应可能的生物学原因；(v) 描述源种群和研究样本中牛群规模的分布。
• Methanesulfonate Esters of Cholane1 Alcohols1All cholane derivatives mentioned in this paper ere 5β-cholanca.
  作者：Frederic C. Chang

  DOI：10.1002/jps.2600530904

  日期：1964.9

  Some methanesulfonate esters of cholane alcohols derived from desoxycholic acid have been prepared and submitted for screening as antitumor agents. Infrared spectra of the dimesylates have distinctive patterns in the 870 to 1000 cm. −1 region, each of which is shown to be virtually superimposable on a composite spectrum of a pair of corresponding mono-mesylates. Antitumor screening test results indicate

  已经制备了一些由脱氧胆酸衍生的胆甾醇的甲磺酸酯，并将其作为抗肿瘤剂进行筛选。二甲基化产物的红外光谱在870至1000厘米范围内具有独特的图案。-1区，每个区显示为实际上可重叠在一对相应的单甲磺酸酯的复合光谱上。抗肿瘤筛选测试结果表明3α，12α-和12α，24化合物对测试动物无活性且无害，但3α，24-异构体的毒性却很大。