| 943314-50-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 943314-50-9
• 化学式: C₃₀H₃₀N₄NiO₆S₂
• 分子量: 665.413
• InChiKey: SOUAPKOQEPMZGJ-HPYVNBGCSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  nickel(II) chloride hexahydrate 、 (E)-4-(2-((2-hydroxybenzylidene)amino)ethyl)benzenesulfonamide 以 甲醇 为溶剂， 以29%的产率得到
  参考文献：
  名称：

  Transition metal complexes (M=Cu, Ni and Mn) of Schiff-base ligands: Syntheses, crystal structures, and inhibitory bioactivities against urease and xanthine oxidase

  摘要：

  Six new transition metal complexes (M=Cu(II), Ni(II) and Mn(III)) of tridentate (H2L1, HL2) and/or bidentate (HL3, HL4) Schiff-base ligands, obtained from the condensation of salicylaldehyde with glycine, N-(2-aminoethyl)morpholine, 4-(2-aminoethyl)phenylic acid and 4-(2-aminoethyl)benzsulfamide, respectively, were synthesized and structurally determined by single-crystal X-ray analysis. Complexes 1-6 were evaluated for their effect on the jack bean urease and xanthine oxidase (XO). Copper(II) complexes 1-3 (IC50=0.43-2.25 mu M) showed potent inhibitory activity against jack bean urease, comparable with acetohydroxamicacid (IC50=42.12 mu M), which is a positive reference. And these copper(II) complexes (IC50=10.26-15.82 mu M) also exhibited strong ability to inhibit activity of XO, comparable to allopurinol (IC50=10.37 mu M), which was used as a positive reference. Nickel(II) and manganese(III) complexes 4-6 showed weak inhibitory activity to jack bean urease (IC50=4.36-8.25 mu M) and no ability to inhibit XO (IC50>100 mu M). (C) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2007.02.019