N-2-<(2-amino-4-thiazolyl)ethyl>-3,4,5-trimethoxyphenylacetamide | 221658-91-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-2-<(2-amino-4-thiazolyl)ethyl>-3,4,5-trimethoxyphenylacetamide
• 英文别名: N-[2-(2-amino-1,3-thiazol-4-yl)ethyl]-2-(3,4,5-trimethoxyphenyl)acetamide
• CAS: 221658-91-9
• 化学式: C₁₆H₂₁N₃O₄S
• 分子量: 351.426
• InChiKey: VCQZSACNKZISPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-2-<(2-amino-4-thiazolyl)ethyl>-3,4,5-trimethoxyphenylacetamide 在 三氯氧磷 、 sodium tetrahydroborate 作用下， 以 CH₃CN 、 甲醇 为溶剂， 反应 5.5h， 生成 2-amino-4-(3',4',5'-trimethoxyphenylmethyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
  参考文献：
  名称：

  Beta3-Adrenoreceptor agonists, agonist compositions and methods of using

  摘要：

  该发明提供了β3-肾上腺素受体激动剂，包括β3-肾上腺素受体激动剂化合物的药物组合物，以及使用这些化合物来刺激、调节或调节动物脂肪组织中脂肪代谢的方法。

  公开号：

  US20040019079A1
• 作为产物：
  描述：

  3,4,5-三甲氧基苯乙酸 在 sodium hydroxide 、 草酰氯 作用下， 以 氯仿 、 苯 为溶剂， 反应 5.0h， 生成 N-2-<(2-amino-4-thiazolyl)ethyl>-3,4,5-trimethoxyphenylacetamide
  参考文献：
  名称：

  2-Amino-4-benzyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridines:  Novel Selective β₃-Adrenoceptor Agonists

  摘要：

  Trimetoquinol (TMQ, 7) is a potent nonselective beta-adrenoceptor (AR) agonist. Replacement of the catechol moiety of TMQ with a 2-aminothiazole group resulted in novel thiazolopyridine derivatives 9-11 which have been synthesized and evaluated for biological activity on human beta(1)-, beta(2)-, and beta(3)-AR. The Bisckler-Napieralski reaction has been employed as a novel approach to construct the 2-amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine ring system. Although in radioligand binding studies analogues 9 and 10 did not show selectivity toward beta(3)-AR, they exhibited a high degree of selective beta(3)-AR agonist activity in functional assays. Moreover, the beta(3)-AR agonist activity of the 2-aminothiazole derivatives is abolished by N-acetylation (analogue 11) or ring opening (analogue 25). This illustrates the importance of the intact 2-amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine ring for beta(3)-AR activity.

  DOI：

  10.1021/jm990012z

文献信息

• Beta3-Adrenoreceptor agonists, agonist compositions and methods of using
  申请人：——

  公开号：US20040019079A1

  公开（公告）日：2004-01-29

  The invention provides &bgr; 3 -adrenoreceptor agonists, pharmaceutical compositions comprising &bgr; 3 -adrenoreceptor agonist compounds, and methods of using such compounds for stimulating, regulating or modulating metabolism of fats in adipose tissue in animals.

  该发明提供了β3-肾上腺素受体激动剂，包括β3-肾上腺素受体激动剂化合物的药物组合物，以及使用这些化合物来刺激、调节或调节动物脂肪组织中脂肪代谢的方法。
• 2-Amino-4-benzyl-4,5,6,7-tetrahydrothiazolo[5,4-<i>c</i>]pyridines:  Novel Selective β₃-Adrenoceptor Agonists
  作者：Weiping Zheng、Victor I. Nikulin、Anish A. Konkar、Sandeep S. Vansal、Gamal Shams、Dennis R. Feller、Duane D. Miller

  DOI：10.1021/jm990012z

  日期：1999.6.1

  Trimetoquinol (TMQ, 7) is a potent nonselective beta-adrenoceptor (AR) agonist. Replacement of the catechol moiety of TMQ with a 2-aminothiazole group resulted in novel thiazolopyridine derivatives 9-11 which have been synthesized and evaluated for biological activity on human beta(1)-, beta(2)-, and beta(3)-AR. The Bisckler-Napieralski reaction has been employed as a novel approach to construct the 2-amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine ring system. Although in radioligand binding studies analogues 9 and 10 did not show selectivity toward beta(3)-AR, they exhibited a high degree of selective beta(3)-AR agonist activity in functional assays. Moreover, the beta(3)-AR agonist activity of the 2-aminothiazole derivatives is abolished by N-acetylation (analogue 11) or ring opening (analogue 25). This illustrates the importance of the intact 2-amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine ring for beta(3)-AR activity.