| 1246746-97-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• CAS: 1246746-97-3
• 化学式: C₄₀H₈₀NO₈P
• 分子量: 734.051
• InChiKey: RWXHFKHLIGCCHT-XPSQVAKYSA-N

反应信息

• 作为产物：
  描述：

  在 10% palladium on carbon 、 氢气 作用下， 生成
  参考文献：
  名称：

  Asymmetric synthesis and structure elucidation of a glycerophospholipid from Mycobacterium tuberculosis

  摘要：

  A glycerophospholipid (1-O-tuberculostearoyl-2-O -palmitoyl-sn-glycero-3-phosphoethanolamine) from Mycobacterium tuberculosis was isolated from the reference strain H37Rv. The molecular structure of this tuberculostearoyl [(R)-10-methyloctadecyl] and palmitoyl containing phosphatidylethanolamine (PE) has been resolved. The substitution pattern on the glycerol backbone could be determined by comparison of the isolate to the two synthetically prepared regioisomers. MS/MS analysis was used to determine its molecular structure. Production of this synthetic version of mycobacterial PE in high yield, with a stereochemically correct and pathogen-specific fatty acyl group, can be used as a standard in LC-MS based lipidomic analyses to detect trace amounts of mycobacterial PE in human blood, sputum, or tissues as a marker of infection by mycobacteria.-ter Horst, B., C. Seshadri, L. Sweet, D. C. Young, B. L. Feringa, D. B. Moody, and A. J. Minnaard. Asymmetric synthesis and structure elucidation of a glycerophospholipid from Mycobacterium tuberculosis. J. Lipid Res. 2010. 51: 1017-1022.

  DOI：

  10.1194/jlr.m001982