(E)-o-hydroxybenzophenone oxime | 59986-60-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-o-hydroxybenzophenone oxime
• 英文别名: 2-oxy-benzophenone-α oxime；2-Oxy-benzophenon-α-oxim；(2-Hydroxyphenyl)(phenyl)methanone oxime；2-[(E)-N-hydroxy-C-phenylcarbonimidoyl]phenol
• CAS: 59986-60-6
• 化学式: C₁₃H₁₁NO₂
• 分子量: 213.236
• InChiKey: HZXQKZWVTDAZAE-BUHFOSPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-o-hydroxybenzophenone oxime 以28%的产率得到
  参考文献：
  名称：

  OHSAWA, AKIO;KAWAGUCHI, TAKAYUKI;IGETA, HIROSHI, CHEM. AND PHARM. BULL., 1982, 30, N 12, 4352-4358

  摘要：

  DOI：
• 作为产物：
  描述：

  2-羟基二苯甲酮 在 氢氧化钾 、 盐酸羟胺 作用下， 生成 (E)-o-hydroxybenzophenone oxime
  参考文献：
  名称：

  THE OXIMES OF ORTHO HYDROXY BENZOPHENONE

  摘要：

  DOI：

  10.1021/ja01355a061

文献信息

• Reactivity of Aromatic<i>o</i>-Hydroxy Oximes. I. Synthesis and Aminolysis of Acylglycine Esters of Aromatic<i>o</i>-Hydroxy Oximes
  作者：Ikuo Hayashi、Keizo Ogihara、Kiyoshi Shimizu

  DOI：10.1246/bcsj.56.2432

  日期：1983.8

  o-hydroxybenzaldehyde oxime, o-hydroxyacetophenone oxime, o-hydroxybenzophenone oxime, and their 5-Cl and 5-NO2 derivatives were prepared by several methods. For aminolysis with benzylamine, esters 1 show higher reactivity than similar esters containing no hydroxyl group in the ortho position. It is suggested that esters 1 forms an intramolecular hydrogen bond between the hydrogen of the hydroxyl group at the ortho

  甘氨酸与邻羟基苯甲醛肟、邻羟基苯乙酮肟、邻羟基二苯甲酮肟及其 5-Cl 和 5-NO2 衍生物的活性酯 (1) 通过多种方法制备。对于用苄胺进行氨解，酯 1 显示出比邻位不含羟基的类似酯更高的反应性。这表明酯1在邻位羟基的氢和羟基亚氨基氮之间形成分子内氢键，从而使其羰基被活化以进行氨解；这种活化机制似乎是一种“分子内酸催化”。在酯系列 1 中，邻羟基苯甲醛肟及其 5-Cl 和 5- 衍生物的酯在氨解中的反应性最强。
• Novel beta-oximinoalkylphosphonic acid ester derivatives and method of preparation
  申请人：ALLIED CORPORATION

  公开号：EP0086936A1

  公开（公告）日：1983-08-31

  Novel β-oximinoalkylphosphonic acid ester derivatives of general formula 8 are prepared from the corresponding α-halo oxime A: wherein R' is a substituent selected from the group consisting of H and C1-C20 alkyl, cycloalkyl and aryl substituents; R2 is a substituent selected from the group consisting of H and C, to C20 linear alkyl and aryl substituents; R3 is a substituent selected from the group consisting of H and C, to C20 alkyl, cycloalkyl, 1-alkoxy alkyl, aryl, acyl, N-substituted carbamoyl, N,N-disubstituted carbamoyl and nitrogen-, oxygen-, sulfur-, and phosphorus-containing heterocyclic substituents; R4 is an alkyl substituent of C, to C20 and X is a substituent selected from the group consisting of Cl, Br, I. In a specific reaction, the a-halo oxime derivative is dissolved in an excess of trialkyl phosphite, greater than 3 molar equivalents is preferred. The preference for the a-halogen atom follows the order I>>Br>>Cl which parallels their rate of reaction with trialkyl phosphite. The acceptable temperature range includes ambient conditions. The reaction can be run in various solvents including tetrahydrofuran, toluene and acetonitrile.

  由相应的α-卤代肟 A 制备通式 8 的新型β-氧亚氨基烷基膦酸酯衍生物： 其中 R' 是选自 H 和 C1-C20 烷基、环烷基和芳基取代基组成的取代基； R2 是选自 H 和 C1-C20 直链烷基和芳基取代基组成的取代基； R3 是选自 H 和 C 至 C20 直链烷基、环烷基、1-烷氧基烷基、芳基、酰基、N-取代氨基甲酰基、N,N-二取代氨基甲酰基和含氮、氧、硫和磷的杂环取代基组成的取代基； R4 是 C 至 C20 的烷基取代基，以及 X 是选自 Cl、Br、I. 在特定的反应中，a-卤代肟衍生物溶解在过量的三烷基亚磷酸酯中，优选大于 3 摩尔当量。a-卤素原子的优先选择顺序为 I>>Br>>Cl，这与它们与亚磷酸三烷基酯的反应速度相一致。可接受的温度范围包括环境条件。反应可在四氢呋喃、甲苯和乙腈等多种溶剂中进行。
• Concentrated solutions of oxime metal extractants and method of formulating extractant compositions therefrom
  申请人：——

  公开号：US20020157572A1

  公开（公告）日：2002-10-31

  The preparation of concentrated solutions of oxime metal extractants, such as aldoximes and ketoximes, or mixtures of aldoxime and ketoxime, and the use thereof in formulating or preparing extraction reagent compositions for use in an extractant organic phase in a process of extracting metals from aqueous solutions containing metal values; and in particular, to concentrates which are solutions of individual ketoxime or aldoxime or mixtures of water-insoluble hydroxy aldoximes and ketoximes, in varying ratios by weight of 1:100 aldoxime to ketoxime, or conversely, 100:1 ketoxime to aldoxime, in water-immiscible hydrocarbon solvents or equilibrium modifiers. The invention also provides for maintaining stability of concentrates determined by accelerating rate calorimetry to define the ranges of oxime concentration and volume whereby the concentrate will be a stable, flowable, pourable and pumpable concentrate which can be safely stored long term. The extraction compositions may also optionally contain equilibrium modifiers or kinetic additives.

  制备肟类金属萃取剂，如醛肟和酮肟，或醛肟和酮肟混合物的浓缩溶液，并将其用于配制或制备萃取试剂组合物，以便在从含有金属价值的水溶液中萃取金属的工艺中用于萃取剂有机相；特别是制备单个酮肟或醛肟，或水不溶性羟基醛肟和酮肟混合物的溶液浓缩物，其重量比为1：在不溶于水的烃类溶剂或平衡调节剂中，醛肟与酮肟的重量比为 1:100，反之，酮肟与醛肟的重量比为 100:1。本发明还提供了保持浓缩物稳定性的方法，通过加速度量热法确定肟的浓度和体积范围，从而使浓缩物成为稳定、可流动、可浇注和可泵送的浓缩物，并可安全地长期储存。萃取组合物还可选择含有平衡调节剂或动力学添加剂。
• The Action of Alkali on Acylated Ketoximes. III. Hydrogen Bond Formation in Derivatives of the o-Hydroxybenzophenone Oximes
  作者：A. H. Blatt、Lillian A. Russell

  DOI：10.1021/ja01301a021

  日期：1936.10
• Meisenheimer; Dorner, Justus Liebigs Annalen der Chemie, 1933, vol. 502, p. 156,173
  作者：Meisenheimer、Dorner

  DOI：——

  日期：——