4-乙基苯肼 | 54840-34-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-乙基苯肼
• 中文别名: (4-乙基苯基)-肼
• 英文名称: p-ethyl-phenylhydrazine
• 英文别名: (4-ethylphenyl)hydrazine
• CAS: 54840-34-5
• 化学式: C₈H₁₂N₂
• mdl: MFCD02656461
• 分子量: 136.197
• InChiKey: JYPNYAHCNKRLHG-UHFFFAOYSA-N

物化性质

• 沸点：
  257.6±19.0 °C(Predicted)
• 密度：
  1.056±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  4-乙基苯肼 在 sodium hydride 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 6.0h， 生成 5-Chloro-2-(4-ethylphenyl)-4-(4-methoxyphenoxy)-3-pyridazinone
  参考文献：
  名称：

  Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)

  摘要：

  Novel smallmolecule antagonists ofNPBWR1 (GPR7) are herein reported. A high-throughput screening (HTS) of the Molecular Libraries-Small Molecule Repository library identified 5-chloro-4-(4-methoxyphenoxy)-2-(p-tolyl)pyridazin-3(2H)-one as a NPBWR1 hit antagonist with micromolar activity. Design, synthesis and structure-activity relationships study of the HTS-derived hit led to the identification of 5-chloro-2-(3,5-dimethylphenyl)-4-(4-methoxyphenoxy) pyridazin-3(2H)-one lead molecule with sub-micromolar antagonist activity at the target receptor and high selectivity against a panel of therapeutically relevant off-target proteins. This lead molecule may provide a pharmacological tool to clarify the molecular basis of the in vivo physiological function and therapeutic utility of NPBWR1 in diverse disease areas including inflammatory pain and eating disorders. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.09.074
• 作为产物：
  描述：

  4-乙基苯胺 在 盐酸 作用下， 生成 4-乙基苯肼
  参考文献：
  名称：

  Willgerodt; Harter, Journal fur praktische Chemie (Leipzig 1954), 1905, vol. <2> 71, p. 415

  摘要：

  DOI：

文献信息

• [EN] TETRAZOLINONE COMPOUNDS AND ITS USE AS PESTICIDES<br/>[FR] COMPOSÉS DE TÉTRAZOLINONE ET LEUR UTILISATION EN TANT QUE PESTICIDES
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2013162072A1

  公开（公告）日：2013-10-31

  The present invention provides a compound having an excellent efficacy for controlling pests. A tetrazolinone compound of a formula (1): [wherein R1 represents an C6-C16 aryl group, an C1-C12 alkyl group, or a C3-C12 cycloalkyl group, etc., which each optionally be substituted; R2, R3, R4 and R5 represent independently of each other a hydrogen atom, a halogen atom or an C1-C3 alkyl group, etc.; R6 represents an C1-C6 alkyl group, a C3-C6 cycloalkyl group, a halogen atom, a C1-C6 haloalkyl group, an C2-C6 alkenyl group, an C1-C6 alkoxy group, or a C1-C6 haloalkoxy group, etc.; R7, R8 and R9 represent independently of each other a hydrogen atom, a halogen atom, or an C1-C4 alkyl group, etc.; X represents an oxygen atom or a sulfur atom; and R10 represents an C1-C6 alkyl group, etc.] shows an excellent controlling efficacy on pests.

  本发明提供了一种具有优异杀虫效果的化合物。公式（1）的四唑酮化合物：[其中R1代表C6-C16芳基、C1-C12烷基或C3-C12环烷基等，每个都可以选择性地被取代；R2、R3、R4和R5分别独立地代表氢原子、卤素原子或C1-C3烷基等；R6代表C1-C6烷基、C3-C6环烷基、卤素原子、C1-C6卤代烷基、C2-C6烯基、C1-C6烷氧基或C1-C6卤代烷氧基等；R7、R8和R9分别独立地代表氢原子、卤素原子或C1-C4烷基等；X代表氧原子或硫原子；R10代表C1-C6烷基等]在杀虫方面表现出优异的控制效果。
• [EN] 5- OR 7-AZAINDAZOLES AS BETA-LACTAMASE INHIBITORS<br/>[FR] AZAINDAZOLES EN 5 OU 7 UTILISÉS COMME INHIBITEURS DE BÊTA-LACTAMASE
  申请人：ACRAF

  公开号：WO2020178316A1

  公开（公告）日：2020-09-10

  The present invention relates to β-lactamase inhibitors having the following general formula (I): wherein R1-R4 and X1-X2 are defined in the specification, pharmaceutical composition thereof, and use thereof for the treatment of a bacterial infection, alone or in combination with β-lactam antibiotics and/or other antibiotics and/or other β-lactamase inhibitors.

  本发明涉及具有以下一般式（I）的β-内酰胺酶抑制剂：其中R1-R4和X1-X2在规范中定义，其药物组成物，以及其用于治疗细菌感染的用途，单独或与β-内酰胺类抗生素和/或其他抗生素和/或其他β-内酰胺酶抑制剂结合使用。
• Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists
  作者：Xuqing Zhang、Chaozhong Cai、Michael Winters、Michele Wells、Mark Wall、James Lanter、Zhihua Sui、Jingyuan Ma、Aaron Novack、Imad Nashashibi、Yuanping Wang、Wen Yan、Arthur Suckow、Hong Hua、Austin Bell、Peter Haug、Wilma Clapper、Celia Jenkinson、Joseph Gunnet、James Leonard、William V. Murray

  DOI：10.1016/j.bmcl.2017.06.028

  日期：2017.8

  A novel series of 5-membered heterocycle-containing phenylpropanoic acid derivatives was discovered as potent GPR120 agonists with low clearance, high oral bioavailability and in vivo antidiabetic activity in rodents.

  发现了一系列新型的五元含杂环苯丙酸衍生物，作为强效的GPR120激动剂，在啮齿类动物中具有低清除率，高口服生物利用度和体内抗糖尿病活性。
• The Preparation of Various New Heterocyclic Compounds via Cyclization of Substituted Derivatives of Phenacyl Esters of Hydrazonoacetic Acid
  作者：Pavel Hradil、Radek Mělnický、Martin Grepl、Antonín Lyčka、Valerio Bertolasi、Lubomír Kvapil、Barbora Dvořáková

  DOI：10.1055/s-0033-1339348

  日期：——

  Abstract A procedure for the preparation of derivatives of phen­acyl hydrazonopropanoates and their application in the synthesis of various heterocycles has been developed. Not only is the preparation of indole derivatives described, but also a new method for the preparation of previously unknown pyridazine derivatives. A procedure for the preparation of derivatives of phen­acyl hydrazonopropanoates

  摘要 已经开发了制备苯甲酰肼基丙酸酯衍生物的方法及其在各种杂环的合成中的应用。不仅描述了吲哚衍生物的制备，而且描述了制备以前未知的哒嗪衍生物的新方法。 已经开发了制备苯甲酰肼基丙酸酯衍生物的方法及其在各种杂环的合成中的应用。不仅描述了吲哚衍生物的制备，而且描述了制备以前未知的哒嗪衍生物的新方法。
• [EN] PREPARATION OF 3-AMINOALKYL-SUBSTITUTED INDOLE DERIVATIVES FROM PHENYLHYDRAZINES AND AMINOKETONES<br/>[FR] PREPARATION DE DERIVES D'INDOLE A SUBSTITUTION 3-AMINOALKYLE A PARTIR DE PHENYLHYDRAZINES ET D'AMINOCETONES
  申请人：SUVEN LIFE SCIENCES LTD

  公开号：WO2004041781A1

  公开（公告）日：2004-05-21

  The present invention relates to a process for the preparation of indole derivatives, particularly those, which are useful as pharmaceutical intermediates. The process involves formation of hydrazone derivative between a phenyl hydrazine and a ketone amine, followed by cyclisation to give desired 2,3-substituted indole derivative in the presence of acid catalyst.

  本发明涉及一种制备吲哚衍生物的方法，特别是那些作为药物中间体有用的衍生物。该方法涉及在酸催化剂存在下，通过苯基肼和酮胺之间的缩醛衍生物的形成，然后进行环化反应，得到所需的2,3-取代吲哚衍生物。