N-(cyclobutyl)-4-iodobenzenesulphonamide | 600700-00-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(cyclobutyl)-4-iodobenzenesulphonamide
• 英文别名: N-cyclobutyl-4-iodobenzenesulfonamide
• CAS: 600700-00-3
• 化学式: C₁₀H₁₂INO₂S
• 分子量: 337.181
• InChiKey: QWADRPSDLKMCDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Pharmaceutical composition containing a heterocyclic modulator of ATP-binding cassette transporters.
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP2395002A1

  公开（公告）日：2011-12-14

  Pharmaceutically acceptable compositions of the present invention are useful as modulators of ATP-Binding Cassette ("ABC") transporters of fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR").

  本发明的药学上可接受的组合物可用作 ATP 结合盒（"ABC"）转运体及其片段的调节剂，包括囊性纤维化跨膜传导调节器（"CFTR"）。
• Modulators of ATP-binding cassette transporters
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US10626111B2

  公开（公告）日：2020-04-21

  Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

  本发明的化合物及其药学上可接受的组合物可用作 ATP 结合盒（"ABC"）转运体或其片段（包括囊性纤维化跨膜传导调节剂（"CFTC"））的调节剂。本发明还涉及使用本发明化合物治疗 ABC 转运体介导的疾病的方法。
• PYRIMIDINE COMPOUNDS
  申请人：AstraZeneca AB

  公开号：EP1485375B1

  公开（公告）日：2009-06-17
• ISOQUINOLINE MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP3012250B1

  公开（公告）日：2017-11-08
• [EN] MORPHOLINYLMETHYLUREAS CCR-3 RECEPTOR ANTAGONIST<br/>[FR] MORPHOLINYLMETHYLURE UTILISEE COMME ANTAGONISTES DU RECEPTEUR CCR-3
  申请人：GLAXO GROUP LTD

  公开号：WO2003099798A1

  公开（公告）日：2003-12-04

  Compounds of formula (I): wherein:R1 represents C3-8 cycloalkyl-Y1-, aryl-Y1-, heteroaryl-Y1-, aryl- G-Y1-, heteroaryl-G-Y1-, C1-6 alkyl-G-Y1-, J1-Y1-, R22R23N-Y1-, R22R23N-CO-Y1- or R24-CONR22-Y1-; Q represents -(CR19R20)(CR19aR20a)t-, wherein t represents an integer from 0 to 3;R2 and R3 independently represent hydrogen or C1-6 alkyl;X represents ethylene or a group of formula CReRf wherein Re and Rf independently represent hydrogen or C1-4 alkyl or Re and Rf may together with the carbon atom to which they are attached form a C3-8 cycloalkyl group; R4 and R5 independently represent hydrogen or C1-4 alkyl; Z represents a bond, CO, SO2, CR10R7(CH2)n, (CH2)nCR10R7, CR10R7(CH2)nO, CR10R7(CH2)nS, CR10R7(CH2)nCO, COCR10R7(CH2)n or SO2CR10R7(CH2)n; R6 represents aryl, heteroaryl or aryl-C2-6 alkenyl-; R7 represents hydrogen, C1-4 alkyl, CONR8R9 or COOC1-6 alkyl;a and b represent 1 or 2, such that a+b represents 2 or 3;G represents -S-, -SO2-, -SO2NR21, -NR21SO2 or -NR21-; n represents an integer from 0 to 4; J1 independently represents a moiety of formula (K): wherein X1 represents oxygen, NR11 or sulphur, X2 represents CH2, oxygen, NR12 or sulphur, m1 represents an integer from 1 to 3, m2 represents an integer from 1 to 3, provided that m1+m2 is in the range from 3 to 5, also provided that when both X1 and X2 represent oxygen, NR11, NR12 or sulphur, m1 and m2 must both not equal less than 2, wherein K is optionally substituted by one or more (eg. 1 or 2) -Y3-aryl, -Y3-heteroaryl, -Y3-CO-aryl, -Y3-CO-heteroaryl, -C1-6 alkyl, -Y3-COOC1-6 alkyl, -Y3-COC1-6 alkyl, -Y3-W, -Y3-CO-W, -Y3-NR15R16, -Y3-CONR15R16, hydroxy, oxo, -Y3-SO2NR15R16, -Y3-SO2C1-6 alkyl, -Y3-SO2aryl, -Y3-SO2heteroaryl, -Y3-NR13C1-6 alkyl, -Y3-NR13SO2C1-6 alkyl, -Y3-NR13CONR15R16, -Y3-NR13COOR14 or -Y3-OCONR15R16 groups, and is optionally fused to a monocyclic aryl or heteroaryl ring;R8, R9, R10, R11, R12, R13 and R14 independently represent hydrogen or C1-6 alkyl; R15 and R16 independently represent hydrogen or C1-6 alkyl or R15 and R16 together with the nitrogen atom to which they are attached may form a morpholine, piperidine or pyrrolidine ring; R17, R18, R19, R20, R19a, R20a, and R21 independently represent hydrogen or C1-4 alkyl; R22 and R23 independently represent hydrogen, C1-6 alkyl, C3-8 cycloalkyl or C3-8cycloalkylC1-6alkyl; R24 represents C1-6 alkyl, C3-8 cycloalkyl, aryl or heteroaryl; W represents a saturated or unsaturated, non-aromatic 5-7