pyridine sulfonyl chloride | 24698-00-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: pyridine sulfonyl chloride
• 英文别名: Pyridine;sulfuryl dichloride
• CAS: 24698-00-8
• 化学式: C₅H₅N*Cl₂O₂S
• 分子量: 214.072
• InChiKey: IAUBZYYUBMBVPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.79
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Protease inhibitors
  申请人：SmithKline Beecham Corporation

  公开号：US20020065230A1

  公开（公告）日：2002-05-30

  The present invention provides bis-aminomethylcarbonyl compounds that are inhibitors of cysteine and serine proteases. The compounds are particularly useful for treating diseases in which excess cysteine protease activity has been implicated, including osteoporosis, periodontitis and arthritis.

  本发明提供了一种双氨甲基羰基化合物，它们是半胱氨酸和丝氨酸蛋白酶的抑制剂。这些化合物特别适用于治疗过多半胱氨酸蛋白酶活性已被指认的疾病，包括骨质疏松症、牙周炎和关节炎。
• Novel Chlorination Reagent and a Novel Process for Chlorination of Sugars Using Thionyl Chloride
  申请人：Ratnam Rakesh

  公开号：US20100228020A1

  公开（公告）日：2010-09-09

  Preparation of chlorinating reagent or chlorination reaction itself for use in a reaction such as production of high intensity sweetener trichlorogalactosucrose (TGS) from partially protected sucrose, comprising reaction of dimethylformamide (DMF) with thionyl chloride or another sulphur containing inorganic acid chlorides including sulphuryl chloride is faced with a problem of prolific release of gaseous by-products, that at times may lead to violent explosion also. This problem is solved by innovative addition of solid powder inert to the constituents of the chlorination reaction mixture to the reaction, or by adding DMF to acid chloride solution in that order. The invention also leads to use of isolated solid Vilsmeier reagent being used for chlorination in a solvent other than DMF making it possible to avoid altogether problems arising from use of DMF which include irrecoverable loss in alkaline as well as acid conditions, interference in crystallization of TGS and the like.

  用于反应中的氯化试剂的制备或氯化反应本身，例如从部分保护的蔗糖中生产高强度甜味剂三氯半乳糖（TGS），包括二甲基甲酰胺（DMF）与氯化亚砜或其他含硫无机酸氯化物（包括亚硫酰氯）反应，面临着大量释放气态副产物的问题，有时甚至可能导致剧烈爆炸。这一问题通过创新地向氯化反应混合物的成分中添加固体粉末惰性物质，或按顺序向酸氯化物溶液中添加DMF来解决。该发明还导致孤立固体维尔斯迈尔试剂用于在非DMF溶剂中进行氯化，从而避免完全使用DMF所带来的问题，包括在碱性和酸性条件下不可恢复的损失，对TGS结晶的干扰等。
• Benzoxazine derivatives and uses thereof
  申请人：Berger Jacob

  公开号：US20050124613A1

  公开（公告）日：2005-06-09

  Compounds of the formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , X, Y and m are as defined herein. Also provided are compositions comprising, methods for using, and methods for preparing compound of formula (I).

  化合物的公式(I)：或其药学上可接受的盐、溶剂合物或前药，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、X、Y和m的定义如本文所述。还提供了包含该化合物的组合物、使用该化合物的方法以及制备该化合物的方法。
• 4-AMINO-5-METHYLPYRAZOLE DERIVATIVES AND PROCESS FOR PRODUCTION THEREOF
  申请人：Sankyo Agro Company, Limited

  公开号：EP1580189A1

  公开（公告）日：2005-09-28

  The present invention relates to 4-amino-5-methylpyrazole derivatives represented by the following formula (I): (wherein R1 represents an isobutyl group, a cyclobutylmethyl group, a neopentyl group or the like) or a salt thereof, which are novel compounds being useful as synthetic intermediates of pharmaceuticals, agricultural chemicals or the like.

  本发明涉及以下式(I)所表示的4-氨基-5-甲基吡唑衍生物（其中R1表示异丁基基团、环丁基甲基基团、新戊基基团或类似物）或其盐，这些新化合物可用作药物、农药或类似物的合成中间体。
• Pyridylsulfonamide derivatives
  申请人：Kling Lothar

  公开号：US20070123513A1

  公开（公告）日：2007-05-31

  The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of such compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.

  本发明涉及式I的化合物：它们的药学上可接受的盐、对映体形式、顺反异构体和混合物，以及这些化合物的制备、含有它们的制药组合物和制造方法，以及在控制或预防癌症等疾病方面使用这些化合物。