N-(3-hydroxy-2-oxopyrid-1-ylacetyl)-N-[3-(3-hydroxy-2-oxopyrid-1-ylacetamido)-propyl]-3-(3-hydroxy-2-oxopyrid-1-ylacetamido)-propylamine | 99110-79-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(3-hydroxy-2-oxopyrid-1-ylacetyl)-N-[3-(3-hydroxy-2-oxopyrid-1-ylacetamido)-propyl]-3-(3-hydroxy-2-oxopyrid-1-ylacetamido)-propylamine
• 英文别名: 2-(3-hydroxy-2-oxopyridin-1-yl)-N-[3-[[2-(3-hydroxy-2-oxopyridin-1-yl)acetyl]-[3-[[2-(3-hydroxy-2-oxopyridin-1-yl)acetyl]amino]propyl]amino]propyl]acetamide
• CAS: 99110-79-9
• 化学式: C₂₇H₃₂N₆O₉
• 分子量: 584.586
• InChiKey: LSPYGUSJLGJORN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  42
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  200
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Hydroxypyridone derivatives and pharmaceutical compositions containing them
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0138421A2

  公开（公告）日：1985-04-24

  Compounds in which two or more rings, being a 3-hydroxpy- pyrid-2-one, 3-hydroxypyrid-4-one or 1-hydroxpyrid-2-one, are linked are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body whilst the iron complexes of such compounds are of value in the treatment of iron deficiency anaemia.

  两个或两个以上环（3-羟基吡啶-2-酮、3-羟基吡啶-4-酮或 1-羟基吡啶-2-酮）相连的化合物对治疗体内金属（尤其是铁）浓度过高的病人很有价值，而此类化合物的铁络合物对治疗缺铁性贫血症很有价值。
• Pharmaceutical compositions
  申请人：BRITISH TECHNOLOGY GROUP LIMITED

  公开号：EP0357150A1

  公开（公告）日：1990-03-07

  Iron complexes of a compound in which 2 or more rings, being a 3-hydroxypyrid-2-one, 3-hydroxypyrid-4- one or 1-hydroxypyrid-2-one, are linked have value in the treatment of iron deficiency anaemia.

  2 个或 2 个以上环（3-羟基吡啶-2-酮、3-羟基吡啶-4-酮或 1-羟基吡啶-2-酮）相连的化合物的铁络合物具有治疗缺铁性贫血症的价值。
• US4912118A
  申请人：——

  公开号：US4912118A

  公开（公告）日：1990-03-27
• US5104865A
  申请人：——

  公开号：US5104865A

  公开（公告）日：1992-04-14