N-methyl-N-(4-chloro-phenyl)-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxamide | 300372-81-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methyl-N-(4-chloro-phenyl)-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxamide
• 英文别名: 5-chloro-N-(4-chlorophenyl)-4-hydroxy-N,1-dimethyl-2-oxoquinoline-3-carboxamide
• CAS: 300372-81-0
• 化学式: C₁₈H₁₄Cl₂N₂O₃
• 分子量: 377.227
• InChiKey: WVMIJXKUTBQGAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  60.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Quinoline derivatives
  申请人：Active Biotech AB

  公开号：US20020173519A1

  公开（公告）日：2002-11-21

  Compounds of formula (I) 1 and tautomers thereof are effective for the treatment of mammals suffering from diseases resulting from autoimmunity and pathological inflammation.

  化合物式(I)1及其互变异构体对于治疗患有自身免疫和病理性炎症引起的疾病的哺乳动物是有效的。
• Phosphonic acid derivative having inhibitory activity against carboxypeptidase B
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1174434A1

  公开（公告）日：2002-01-23

  A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R1 represents hydrogen atom, an alkyl group, a substituted alkyl group and the like; R2 and R3 represent hydrogen atom, an alkyl group, a substituted alkyl group, an alkoxyl group and the like; X represents -CH2-, -O-, or -NH-; A represents the following group (II): [in which R7 and R8 represent hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group and the like; R9 and R10 represents hydrogen atom, a halogen atom, hydroxyl group, phenyl group, an alkyl group and the like] and the like; and E represents hydrogen atom and the like, which has inhibitory activity against carboxypeptidase B and is useful for therapeutic and/or preventive treatment of a thrombotic disease.

  由以下通式（I）代表的化合物及其药理学上可接受的盐： 其中 R1 代表氢原子、烷基、取代的烷基等；R2 和 R3 代表氢原子、烷基、取代的烷基、烷氧基等；X 代表 -CH2-、-O- 或 -NH-；A 代表以下基团 (II)： [其中 R7 和 R8 代表氢原子、烷基、酰基、烷氧基羰基等；R9 和 R10 代表氢原子、卤素原子、羟基、苯基、烷基等]等；E 代表氢原子等，对羧肽酶 B 具有抑制活性，可用于血栓性疾病的治疗和/或预防。
• QUINOLINE DERIVATIVES
  申请人：Active Biotech AB

  公开号：EP1095021B1

  公开（公告）日：2003-09-17
• DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS
  申请人：Active Biotech AB

  公开号：EP1224172A1

  公开（公告）日：2002-07-24
• US6133285A
  申请人：——

  公开号：US6133285A

  公开（公告）日：2000-10-17