4-[2-amino-3-(2-methoxypyridin-5-yl)pyridin-5-yl]-N-cyclopropyl benzamide | 1010381-47-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-[2-amino-3-(2-methoxypyridin-5-yl)pyridin-5-yl]-N-cyclopropyl benzamide
• 英文别名: 4-[6-amino-5-(6-methoxypyridin-3-yl)pyridin-3-yl]-N-cyclopropylbenzamide
• CAS: 1010381-47-1
• 化学式: C₂₁H₂₀N₄O₂
• 分子量: 360.415
• InChiKey: KYGYGFVXGRSHPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  90.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NEW ANTI-MALARIAL AGENTS
  申请人：Witty Michael John

  公开号：US20120295905A1

  公开（公告）日：2012-11-22

  The present invention is related to a use of aminopyridine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyridine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

  本发明涉及氨基吡啶衍生物在制造预防或治疗疟疾药物方面的用途。具体而言，本发明涉及氨基吡啶衍生物，可用于制备制药配方，以抑制疟原虫的增殖。
• Aminopyridine derivatives as kinase inhibitors
  申请人：CELLZOME AG

  公开号：EP1900727A1

  公开（公告）日：2008-03-19

  The invention relates to compounds of formula (I) wherein T1 and T2 have the meaning as cited in the description and the claims. Said compounds are useful as Itk protein kinase inhibitors for the treatment or prophylaxis of immunological, inflammatory or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.

  本发明涉及式 (I) 的化合物 其中 T1 和 T2 具有在说明书和权利要求书中引用的含义。所述化合物可作为 Itk 蛋白激酶抑制剂用于治疗或预防免疫性、炎症性或过敏性疾病。本发明还涉及包括上述化合物的药物组合物、此类化合物的制备以及作为药物的生产和使用。
• US9024033B2
  申请人：——

  公开号：US9024033B2

  公开（公告）日：2015-05-05
• [EN] AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS D'AMINOPYRIDINE EN TANT QU'INHIBITEURS DE KINASE
  申请人：CELLZOME UK LTD

  公开号：WO2008025820A1

  公开（公告）日：2008-03-06

  [EN] The invention relates to compounds of formula (I), wherein T¹ and T² have the meaning as cited in the description and the claims. Said compounds are useful as Itk protein kinase inhibitors for the treatment or prophylaxis of immunological, inflammatory or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.
  [FR] L'invention concerne des composés de formule (I), dans laquelle T¹ et T² ont les significations données dans la description et dans les revendications. Lesdits composés sont utiles en tant qu'inhibiteurs de la protéine kinase Itk pour le traitement ou la prophylaxie de troubles immunologiques, inflammatoires ou allergiques. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés, la préparation de tels composés, ainsi que leur production et leur utilisation en tant que médicaments.
• [EN] NEW ANTI-MALARIAL AGENTS<br/>[FR] NOUVEAUX AGENTS ANTIPALUDIQUES
  申请人：MEDICINES FOR MALARIA VENTURE MMV

  公开号：WO2011086531A2

  公开（公告）日：2011-07-21

  The present invention is related to a use of aminopyridine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyridine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.