sodium cholesterylate | 107612-00-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: sodium cholesterylate
• 英文别名: sodium cholesterate；cholesterol; sodium cholesterylate；Cholesterin; Natrium-cholesterylat；sodium;(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-olate
• CAS: 107612-00-0
• 化学式: C₂₇H₄₅O*Na
• 分子量: 408.643
• InChiKey: VULGUTYJXYTXFO-KPNWGBFJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.76
• 重原子数：
  29.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  23.06
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  sodium cholesterylate 在 乙酸酐 、 三乙胺 作用下， 以 苯 为溶剂， 反应 24.0h， 生成 (E)-2-[(3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-3-(2-methoxy-phenyl)-acrylic acid
  参考文献：
  名称：

  Synthesis, and hypolipidemic and cholagogic activity of cinnamic acid derivatives

  摘要：

  DOI：

  10.1007/bf00777423
• 作为产物：
  描述：

  cholesterol 在 sodium 、 Petroleum ether 作用下， 生成 sodium cholesterylate
  参考文献：
  名称：

  Beiträge zur Kenntniss des Cholesterins

  摘要：

  DOI：

  10.1007/bf01516710

文献信息

• Hypervalent (<i>tert</i>-Butylperoxy)iodanes Generate Iodine-Centered Radicals at Room Temperature in Solution:  Oxidation and Deprotection of Benzyl and Allyl Ethers, and Evidence for Generation of α-Oxy Carbon Radicals
  作者：Masahito Ochiai、Takao Ito、Hideo Takahashi、Akinobu Nakanishi、Mika Toyonari、Takuya Sueda、Satoru Goto、Motoo Shiro

  DOI：10.1021/ja9610287

  日期：1996.1.1

  reductive deprotection. Oxidation with 1a occurs readily with C−H bonds activated by both enthalpic effects (benzylic, allylic, and propargylic C−H bonds) and/or polar effects (α-oxy C−H bonds), generating α-oxy carbon-centered radicals, which can be detected by nitroxyl radical trapping. Measurement of the relative rates of oxidation for a series of ring-substituted benzyl n-butyl ethers 2d and 2p−s

  1-(tert-Butylperoxy)-1,2-benziodoxol-3(1H)-one (1a) 在室温下，在苯或环己烷中，在碱金属碳酸盐存在下，将苄基和烯丙基醚氧化成酯。由于该反应与其他保护基团（例如 MOM、THP 和 TBDMS 醚以及乙酰氧基）相容，并且由于酯在碱性条件下容易水解，因此这种新方法为通常的还原性脱保护提供了一种方便有效的替代方法。与 1a 的氧化很容易发生，C-H 键被焓效应（苄基、烯丙基和炔丙基 C-H 键）和/或极性效应（α-氧 C-H 键）激活，生成 α-氧碳中心自由基，可以通过硝酰基自由基捕获来检测。
• Detection of Viable Rotaviruses in Shellfish by means of Cell Culture and Immunofluorescence Assay
  作者：C. S. Santos、C. Rigotto、C.M.O. Simoes、C.R.M. Barardi

  DOI：10.1111/j.1365-2621.2002.tb08738.x

  日期：2002.6

  ABSTRACT: The goal of this work was to examine the use of cell culture and immunofluorescence assays to detect viable rotaviruses in artificially seeded oyster meat and to determine if the method for oyster extracts preparation affects the viability of the viruses. Oyster tissues were seeded with rotavirus SA11, followed by tissue extract preparation. For cytopathogenicity assays (CPE), non‐cytotoxic dilutions of seeded oyster extracts were inoculated in MA 104 cells. For immunofluorescence assays (IFA) the monoclonal antibody Mab M60 anti‐VP7 capsid glycoprotein of rotavirus was used. For CPE tests, no significant difference between the oyster extracts inoculated with rotavirus before and after extract preparation was detected. Similar results have been observed in IFA assays and the recoveries of viable rotavirus obtained were close to 100%.
• Lindenmeyer, Journal fur praktische Chemie (Leipzig 1954), 1863, vol. <1> 90, p. 321,326
  作者：Lindenmeyer

  DOI：——

  日期：——
• Preparation and spectral properties of lipophilic fluorescein derivatives: application to plasma low-density lipoprotein
  作者：J. R. Falck、Monty Krieger、J. L. Goldstein、M. S. Brown

  DOI：10.1021/ja00414a087

  日期：1981.12