(R)-tert-butyl(5-(4-methoxybenzyloxy)pent-1-yn-3-yloxy)diphenylsilane | 1195470-81-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-tert-butyl(5-(4-methoxybenzyloxy)pent-1-yn-3-yloxy)diphenylsilane
• CAS: 1195470-81-5
• 化学式: C₂₉H₃₄O₃Si
• 分子量: 458.673
• InChiKey: AVNCDYCCTKQEKQ-VWLOTQADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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文献信息

• Total synthesis of resolvin E1
  作者：Narihito Ogawa、Yuichi Kobayashi

  DOI：10.1016/j.tetlet.2009.08.061

  日期：2009.11

  endogenous mediator to resolve inflammation, was synthesized by Wittig reaction between the C15–C20 aldehyde and the C10–C14 phosphonium salt possessing the vinyl iodo moiety followed by Suzuki–Miyaura coupling of the resulting vinyl iodide with the vinyl borane of the C1–C9 part, which was derived from the corresponding acetylene by hydroboration. The C5 and C18 chiral centers in these parts were created

  Resolvin E1（RvE1）是解决炎症的内源性介质，它是通过C15–C20醛与具有乙烯基碘部分的C10–C14 nium盐之间的Wittig反应合成，然后将生成的碘代乙烯基碘与Suzuki-Miyaura偶联的C1-C9部分的乙烯基硼烷，是通过硼氢化从相应的乙炔衍生而来的。这些部分的C5和C18手性中心是由外消旋的γ-TMS烯丙基醇通过不对称环氧化反应动力学拆分而形成的，而C10–C14的手性中心是由相应的γ-TMS的不对称氢转移反应构建的乙炔酮。
• Stereoselective total synthesis of (+)-hyptolide
  作者：Gowravaram Sabitha、A. Raju、C. Nagendra Reddy、J. S. Yadav

  DOI：10.1039/c3ra45042b

  日期：——

  Stereoselective synthesis of the naturally occurring 6-membered lactone hyptolide 1 is described. The main feature of the synthesis is the utility of the hitherto unexplored alkyne fragment derived from commercially available 3-butyn-1-ol (homopropargylic alcohol).

  描述了天然存在的 6 元内酯 Hyptolide 1 的立体选择性合成。该合成的主要特点是利用了迄今为止尚未开发的源自市售 3-丁炔-1-醇（高炔丙醇）的炔烃片段。
• Combined solution-phase and solid-phase synthesis of 2-amino-7,8-dihydropteridin-6(5H)-ones
  作者：Axel Metzger、Lan-Ying Qin、Andrew G. Cole、Kurt W. Saionz、Marc-Raleigh Brescia、Hubert Gstach、James R. Wareing、Juerg Zimmermann、Wolfgang K-D. Brill、John J. Baldwin、Roland E. Dolle、Ian Henderson

  DOI：10.1016/j.tetlet.2009.10.005

  日期：2009.12

  An efficient and general synthesis of substituted 2-amino-7,8-dihydropteridin-6(5H)-ones using a combination of solution-phase and solid-phase chemistry is described. Solution-phase chemistry was used to produce two pyrimidine regioisomers that were separated by flash column chromatography. Utilizing the desired regioisomer, solid-phase chemistry Was used to effect the rapid construction of the substituted 2-amino-7,8-dihydropteridin-6(5H)-one system in high overall yield and purity. (C) 2009 Elsevier Ltd. All rights reserved.