泼尼松龙苯酰磺酸钠 | 630-67-1

• 物质功能分类: 化学试剂 - 有机试剂
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 泼尼松龙苯酰磺酸钠
• CAS: 630-67-1
• 化学式: C28H32NaO9S
• 分子量: 567.6
• InChiKey: NGBAZAFEHFURDY-VDYYWZOJSA-N

物化性质

• 熔点：
  >88°C (dec.)
• 比旋光度：
  D20 +170° (water)
• 溶解度：
  可溶于DMSO（轻微）、甲醇（轻微）、水（轻微、超声处理）

计算性质

• 辛醇/水分配系数(LogP)：
  2.29
• 重原子数：
  39
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  164
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Compositions, formulations and kit with anti-sense oligonucleotide and anti-inflammatory steroid and/or obiquinone for treatment of respiratory and lung disesase
  申请人：Nyce W. Jonathan

  公开号：US20070021360A1

  公开（公告）日：2007-01-25

  A pharmaceutical composition and formulations comprise preventative, prophylactic or therapeutic amounts of an oligo(s) anti-sense to a specific gene(s) or its corresponding mRNA(s), and a glucocorticoid and/or non-glucocorticoid steroid or a ubiquinone or their salts. The agents, composition and formulations are used for treatment of ailments associated with impaired respiration, bronchoconstriction, lung allergy(ies) or inflammation, and abnormal levels of adenosine, adenosine receptors, sensitivity to adenosine, lung surfactant and ubiquinone, such as pulmonary fibrosis, vasoconstriction, inflammation, allergies, allergic rhinitis, asthma, impeded respiration, lung pain, cystic fibrosis, bronchoconstriction, COPD, RDS, ARDS, cancer, and others. The present treatment is effectively administered by itself for conditions without known therapies, as a substitute for therapies exhibiting undesirable side effects, or in combination with other treatments, e.g. before, during and after other respiratory system therapies, radiation, chemotherapy, antibody therapy and surgery, among others. Each of the agents of this invention may be administered directly into the respiratory system so that they gain direct access to the lungs, or by other effective routes of administration. A kit comprises a delivery device, the agents and instructions for its use.
• US4296109A
  申请人：——

  公开号：US4296109A

  公开（公告）日：1981-10-20