norcholest-5-en-3-one | 56997-89-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: norcholest-5-en-3-one
• 英文别名: A-nor-cholest-5-en-3-one；A-Nor-cholest-5-en-3-on；A-Nor-cholesten-(5)-on-(3)；A-Norcholest-5-en-3-on；A-Norcholesten-5-on-3
• CAS: 56997-89-8
• 化学式: C₂₆H₄₂O
• 分子量: 370.619
• InChiKey: USIDJRVSJYRFRN-MEJHGOECSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.21
• 重原子数：
  27.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  norcholest-5-en-3-one 在 乙醚 、 magnesium,propane,iodide 作用下， 生成 6ξ-isopropyl-A-nor-5ξ-cholestan-3-one
  参考文献：
  名称：

  154. 4：4-二甲基胆甾-5-en-3β-甲苯基-对磺酸盐的溶剂分解

  摘要：

  DOI：

  10.1039/jr9590000769
• 作为产物：
  描述：

  cholesterol 在 次溴酸钾 作用下， 生成 norcholest-5-en-3-one
  参考文献：
  名称：

  478.类固醇。第三部分 3-甲基-A-降胆固醇-3（5）-烯

  摘要：

  DOI：

  10.1039/jr9520002528

文献信息

• Structure – chiroptical properties relationship of cisoid enones with an α-methylenecyclopentanone unit
  作者：Jadwiga Frelek、Aleksandra Butkiewicz、Marcin Górecki、Ryszard K. Wojcieszczyk、Roman Luboradzki、Marcin Kwit、Michał F. Rode、Wojciech J. Szczepek

  DOI：10.1039/c4ra04991h

  日期：——

  In the present work, the validity of sector and helicity rules correlating the stereostructure of cis-enones containing the 2-methylenecyclopentanone unit with the sign of the nπ* Cotton effect (CE) observed in their electronic circular dichroism (ECD) spectra is assessed. To this end, a series of model steroid cis-enones with five-membered ketone rings was synthesized. To investigate the scope and limitations of existing rules a combination of ECD spectroscopy, X-ray analysis, and time-dependent density functional theory (TD-DFT) calculations were utilized. A comparison of the experimental ECD spectra with spectra simulated by the TD-DFT calculations gave a reasonable interpretation of the nπ* CE's observed in the 360–335 nm spectral range. The results suggest that the previously articulated rules are not applicable to the investigated compounds. On the basis of comprehensive analysis of collected data, a new rule correlating perfectly the structure of studied enones with the signs of their nπ* CE was proposed. This rule correlates directly the sign of the torsion angle “b” of the cyclopentanone ring of cis-enone with the sign of the nπ* CE.

  在本研究工作中，评估了与含有2-亚甲基环戊酮单元的顺式环烯酮的立体结构相关的扇区和螺旋规则的有效性，这些规则关联了它们在电子圆二色性(ECD)光谱中观察到的n→π* Cotton效应(CE)的符号。为此，合成了一系列具有五元酮环的模型甾体顺式环烯酮。为了探究现有规则的适用范围和局限性，采用了ECD光谱学、X射线分析和含时密度泛函理论(TD-DFT)计算相结合的方法。通过比较实验ECD光谱与由TD-DFT计算模拟的光谱，对在360-335 nm光谱范围内观察到的n→π* CE给出了合理的解释。结果表明，先前阐述的规则不适用于所研究的化合物。基于对收集数据的全面分析，提出了一条与所研究环烯酮结构完美关联的新规则，该规则直接关联顺式环烯酮的环戊酮环的扭转角“b”的符号与n→π* CE的符号。
• The Solvolysis of 4,4-Dimethylcholesteryl p-Toluenesulfonate
  作者：ROBERT M. MORIARTY、EVERETT S. WALLIS

  DOI：10.1021/jo01091a029

  日期：1959.9
• Auditory Model Enhances Relative-Timing Learning
  作者：Qin Lai、Charles H. Shea、Lisa Bruechert、Mark Little

  DOI：10.1080/00222890209601948

  日期：2002.9

  In recent experiments (Q. Lai, C. H. Shea, & M. Little, 2000; C. H. Shea, G. Wulf, J. Park, & B. Gaunt, 2001), auditory models were found to be effective in enhancing relative-timing performance and learning in constant practice conditions. In the present experiment, the authors examined (a) whether an auditory model also enhances relative-timing learning in blocked and random practice conditions and (b) whether experience with the auditory model enhances participants' ability to produce the response by using different effector sequences. Participants (N = 48) were randomly assigned to 1 of 4 acquisition conditions in which an auditory model was or was not present and the practice schedule was blocked or random. In the acquisition phase, all participants alternately pressed 2 keys on a keyboard in an attempt to match 5 goal intervals. In the auditory model conditions, a sequence of tones was played before each acquisition trial. The tones represented the correct timing sequence for that trial. One retention and 3 effector-transfer tests without feedback were administered about 24 hr after the completion of acquisition. The results indicated that the auditory model enhanced relative-timing performance and learning independently of practice schedule. In addition, the auditory model enhanced relative timing on the effector-transfer tests, but absolute-timing performance and learning were not affected by the auditory model. Thus, relative timing was found to be effector independent but absolute timing was not.
• Audouin,M.; Levisalles,J., Bulletin de la Societe Chimique de France, 1975, p. 695 - 701
  作者：Audouin,M.、Levisalles,J.

  DOI：——

  日期：——
• Windaus, Chemische Berichte, 1912, vol. 45, p. 1316,1317
  作者：Windaus

  DOI：——

  日期：——