perfluoro-4-t-butyl-1-methylcyclohexane | 75169-50-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: perfluoro-4-t-butyl-1-methylcyclohexane
• 英文别名: perfluoro-1-methyl-4-tert-butylcyclohexane；Perfluoro(1-methyl-4-t-butylcyclohexane)；1,1,2,2,3,4,4,5,5,6-decafluoro-3-[1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-yl]-6-(trifluoromethyl)cyclohexane
• CAS: 75169-50-5
• 化学式: C₁₁F₂₂
• 分子量: 550.086
• InChiKey: DSHQRENFDMQWER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  33
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  22

文献信息

• Improvements in and relating to a method of detecting a certain gas in an animal
  申请人：CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：EP0118281A2

  公开（公告）日：1984-09-12

  A method to detect indirectly at least one gas, particularly dissolved gases, of an animal employing nuclear magnetic resonance techniques (NMR). The method examines an NMR spectrum to determine chemical shift relaxation times or spin-spin couplings for an element of an animal influenced by at least one gas of the animal, the chemical shift corresponding to the amount or identify of the gas.

  一种利用核磁共振技术（NMR）间接检测动物体内至少一种气体，特别是溶解气体的方法。该方法通过检测核磁共振波谱来确定受动物体内至少一种气体影响的动物元素的化学位移弛豫时间或自旋-自旋耦合，化学位移与气体的量或识别率相对应。
• Method of detecting temperature in an object
  申请人：CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：EP0122000A2

  公开（公告）日：1984-10-17

  A method to detect indirectly a temperature of an object employing nuclear magnetic resonance techniques (NMR). The method involves obtaining an NMR spectrum to determine chemical shift, relaxation times, spin-spin couplings or quadrupole couplings for an element of a compound having at least one conformational isomer wherein the compound is influenced by a temperature of the object. The difference between the detected radio frequency signals for the same element, spectral patterns or chemical shifts corresponds to the temperature of the object.

  一种利用核磁共振技术间接检测物体温度的方法。该方法包括获取核磁共振谱，以确定具有至少一种构象异构体的化合物中某一元素的化学位移、弛豫时间、自旋-自旋耦合或四极耦合，其中该化合物受物体温度的影响。 检测到的同一元素的射频信号、光谱模式或化学位移之间的差异与物体的温度相对应。
• Delivery vehicles for bioactive agents and uses thereof
  申请人：Southern Research Institute

  公开号：US20020169138A1

  公开（公告）日：2002-11-14

  Compositions for transporting a bioactive agent across a biological membrane include the bioactive agent, an oil, an oil-immiscible compound and a noncationic surface active agent. The compositions may deliver the bioactive agent through a chemical microporulation mechanism, which allows transfer of the agent across both cellular, intracellular organelle, and nuclear membranes. Compositions for nucleic acid delivery include nucleic acid, oil, oil-immiscible compound, noncationic surface active agent and essentially no cationic lipid, or include nucleic acid, oil, oil-immiscible compound and two noncationic surface active agents. The nucleic acid may be hydrophobically-modified, and be in combination with an oil, an oil-immiscible compound and at least one surface active agent. The compositions may be used for gene delivery to a cell, as well as delivery of other therapeutic agents.

  用于跨生物膜传输生物活性剂的组合物包括生物活性剂、油、油不溶性化合物和非阳离子表面活性剂。这些组合物可通过化学微孔机制输送生物活性剂，从而实现生物活性剂在细胞膜、细胞内细胞器和核膜上的转移。用于递送核酸的组合物包括核酸、油、油不溶性化合物、非阳离子表面活性剂和基本不含阳离子的脂质，或包括核酸、油、油不溶性化合物和两种非阳离子表面活性剂。核酸可进行疏水改性，并与油、油不混溶化合物和至少一种表面活性剂结合使用。这些组合物可用于向细胞输送基因，也可用于输送其他治疗剂。
• Paramagnetic particles that provide improved relaxivity
  申请人：——

  公开号：US20030185760A1

  公开（公告）日：2003-10-02

  An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as to improve the relaxivity imparted by the contrast agent.

  一种用于磁共振成像的改进型造影剂由颗粒组成，每个颗粒上都耦合了多种含有顺磁离子的螯合剂。在改进型造影剂中，离子的位置偏离颗粒表面，以提高造影剂的弛豫性。
• Extraocular device for treating the eye
  申请人：CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：EP0112658B1

  公开（公告）日：1991-08-07