(1E,4E)-1,4-bis((7-thia-14,15-diazadispiro[5.1.58.26]pentadec-14-en-3-ylidene)hydrazineylidene)cyclohexane | 169822-41-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻烷
• 英文名称: (1E,4E)-1,4-bis((7-thia-14,15-diazadispiro[5.1.58.26]pentadec-14-en-3-ylidene)hydrazineylidene)cyclohexane
• CAS: 169822-41-7
• 化学式: C₃₀H₄₄N₈S₂
• 分子量: 580.865
• InChiKey: HYXGRPLGXNKASN-NETZLRJJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.41
• 重原子数：
  40.0
• 可旋转键数：
  2.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  98.88
• 氢给体数：
  0.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  (1E,4E)-1,4-bis((7-thia-14,15-diazadispiro[5.1.58.26]pentadec-14-en-3-ylidene)hydrazineylidene)cyclohexane 在 硫化氢 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 生成 7,12,17,22-Tetrathia-29,30,33,34,37,38,41,42-octazaoctaspiro[5.1.2.1.2.1.2.1.523.221.218.216.213.211.28.26]dotetraconta-29,41-diene
  参考文献：
  名称：

  Oligo(cyclohexylidenes): Parent Compounds and End-Functionalized Derivatives

  摘要：

  Parent oligo(cyclohexylidenes) 1(n) (n = 1-4) were synthesized using a modified Barton-Kellogg olefin synthesis. Surprisingly, the crude compounds 1(2) and 1(4) contained small amounts of the 1(n-1) and 1(n+1) homologues. As evidenced by a close examination of mass spectral data of selectively deuterated tercyclohexylidenes 1(2)d(4)d(4) and 1(2)-d(8), their formation can be attributed to scrambling of the intermediate azines. With increasing n, a marked decrease in solubility as well as an increase in thermal stability was found. Powder diffraction measurements indicate that the parent compounds 1(n), irrespective of n, pack in a similar fashion in the solid state. The theoretically (MMX, AM1, and ab initio) predicted rodlike structure of the oligo(cyclohexylidenes) was confirmed by single-crystal X-ray structures of 1(1) and three derivatives (12(1), 13(1), and 30(2)). In line with the powder diffraction data in the series 1(n), a similar packing motif was found for the derivatives. To circumvent side product formation due to azine scrambling, a different synthetic approach was used for the preparation of end-functionalized oligo(cyclohexylidenes), i.e. decarboxylation and dehydration of beta-hydroxy acids.

  DOI：

  10.1021/jo00119a014
• 作为产物：
  描述：

  1,4-环己二酮 在 sodium hydride 、 溶剂黄146 、 sodium sulfate 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (1E,4E)-1,4-bis((7-thia-14,15-diazadispiro[5.1.58.26]pentadec-14-en-3-ylidene)hydrazineylidene)cyclohexane
  参考文献：
  名称：

  Oligo(cyclohexylidenes): Parent Compounds and End-Functionalized Derivatives

  摘要：

  Parent oligo(cyclohexylidenes) 1(n) (n = 1-4) were synthesized using a modified Barton-Kellogg olefin synthesis. Surprisingly, the crude compounds 1(2) and 1(4) contained small amounts of the 1(n-1) and 1(n+1) homologues. As evidenced by a close examination of mass spectral data of selectively deuterated tercyclohexylidenes 1(2)d(4)d(4) and 1(2)-d(8), their formation can be attributed to scrambling of the intermediate azines. With increasing n, a marked decrease in solubility as well as an increase in thermal stability was found. Powder diffraction measurements indicate that the parent compounds 1(n), irrespective of n, pack in a similar fashion in the solid state. The theoretically (MMX, AM1, and ab initio) predicted rodlike structure of the oligo(cyclohexylidenes) was confirmed by single-crystal X-ray structures of 1(1) and three derivatives (12(1), 13(1), and 30(2)). In line with the powder diffraction data in the series 1(n), a similar packing motif was found for the derivatives. To circumvent side product formation due to azine scrambling, a different synthetic approach was used for the preparation of end-functionalized oligo(cyclohexylidenes), i.e. decarboxylation and dehydration of beta-hydroxy acids.

  DOI：

  10.1021/jo00119a014