4-乙酰基-5-(3,4-二甲氧苯基)二氢呋喃-2(3H)-酮 | 147353-44-4

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 阿朴菲
• 中文名称: 4-乙酰基-5-(3,4-二甲氧苯基)二氢呋喃-2(3H)-酮
• 英文名称: (6Ar)-6,6a-dimethyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-10,11-diol
• CAS: 147353-44-4
• 化学式: C₁₈H₁₉NO₂
• 分子量: 281.3
• InChiKey: RPTVQUIRIZNRJB-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• PHARMACOLOGICAL AGENTS FOR TREATING OCULAR DISEASES
  申请人：CALASIA PHARMACEUTICALS, INC.

  公开号：US20210154213A1

  公开（公告）日：2021-05-27

  Methods of treating presbyopia or cataract in a subject in need thereof are provided. The methods require administering to the subject an effective amount of a composition comprising a compound that inhibits the formation of high molecular weight aggregates of human α-A-crystallin. Compositions containing certain compounds are believed to be also effective in the treatment of transthyretin (TTR)-associated amyloidosis and Parkinson's disease.