3-(4-chloro-benzenesulfonyl)-5,5-diphenyl-imidazolidine-2,4-dione | 24780-73-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-(4-chloro-benzenesulfonyl)-5,5-diphenyl-imidazolidine-2,4-dione
• 英文别名: 3-(4-Chlorophenyl)sulfonyl-5,5-diphenylimidazolidine-2,4-dione
• CAS: 24780-73-2
• 化学式: C₂₁H₁₅ClN₂O₄S
• 分子量: 426.88
• InChiKey: JYYNKLVGHHTOHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  91.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• N-CYCLIC SULFONAMIDO INHIBITORS OF GAMMA SECRETASE
  申请人：ELAN PHARMACEUTICALS, INC.

  公开号：EP1758884A2

  公开（公告）日：2007-03-07
• [EN] N-CYCLIC SULFONAMIDO INHIBITORS OF GAMMA SECRETASE<br/>[FR] INHIBITEURS SULFONAMIDO N-CYCLIQUES DE GAMMA-SECRETASE
  申请人：ELAN PHARM INC

  公开号：WO2005113542A2

  公开（公告）日：2005-12-01

  The invention provides N-cyclic sulfonamido compounds for use in treating or preventing cognitive disorders, such as Alzheimer’s Disease. Compounds of particular interest are defined by Formula (I), wherein R4, R5, R6, R7 and R8 are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders, including Alzheimer’s disease using compounds of Formula (I).