1-methylamino-8-nitronaphthalene | 76874-29-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-methylamino-8-nitronaphthalene
• 英文别名: methyl-(8-nitro-[1]naphthyl)-amine；N-methyl-8-nitronaphthalen-1-amine
• CAS: 76874-29-8
• 化学式: C₁₁H₁₀N₂O₂
• 分子量: 202.213
• InChiKey: DGJYXJAPMNIMPC-UHFFFAOYSA-N

物化性质

• 熔点：
  81 °C
• 沸点：
  373.1±22.0 °C(Predicted)
• 密度：
  1.305±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.79
• 重原子数：
  15.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  55.17
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  1-methylamino-8-nitronaphthalene 在 水 、 铁粉 、 溶剂黄146 作用下， 以 xylene 为溶剂， 反应 6.0h， 以95%的产率得到N-methyl-1,8-naphthalenediamine
  参考文献：
  名称：

  Pozharskii, A. F.; Suslov, A. N.; Starshikov, N. M., Journal of Organic Chemistry USSR (English Translation), 1980, vol. 16, p. 1890 - 1901

  摘要：

  DOI：
• 作为产物：
  描述：

  N-methyl-1-p-tolylsulfonylamino-8-nitronaphthalene 在 硫酸 作用下， 反应 3.0h， 以80%的产率得到1-methylamino-8-nitronaphthalene
  参考文献：
  名称：

  Pozharskii, A. F.; Suslov, A. N.; Starshikov, N. M., Journal of Organic Chemistry USSR (English Translation), 1980, vol. 16, p. 1890 - 1901

  摘要：

  DOI：

文献信息

• A comparative study between excess-dose users and regular-dose users of rhubarb contained in Kampo medicines
  作者：N. Mantani、T. Kogure、S. Sakai、M. Kainuma、Y. Kasahara、A. Niizawa、Y. Shimada、K. Terasawa

  DOI：10.1078/09447110260571580

  日期：2002.1

  With prolonged use of rhubarb-containing Kampo medicines, some patients come to ask for highdose rhubarb because of deteriorated reactivity to rhubarb. We divided patients into two groups in terms of rhubarb-dose, and compared clinical backgrounds between regular-dose group and excess-dose group. Patients who were treated with rhubarb-containing Kampo extracts (manufactured prescriptions) or Kampo formulae (decoctions) for more than 12 months were enrolled. These two groups were compared for age, sex, shape of stool, abdominal symptoms, existence of hemorrhoids, Kampo diagnosis of abdomen, past stimulant laxative use, duration of stimulant laxative use before the first administration of rhubarb, duration of rhubarb use in our hospital, and initial existence of stimulant pain caused by taking stimulant laxatives for the first time. No significant difference was shown between the two groups in terms of age, duration of stimulant laxative-use before the first prescription of rhubarb, shape of stool, abdominal symptoms, existence of hemorrhoids, or duration of rhubarb-use. However, most patients in the regular-dose group had initial stimulant pain of the abdomen upon taking stimulant laxatives for the first time, but most patients in the excess-dose group did not (p < 0.001). All patients except one in the regular dose group had the sign of "umbilical region tenderness on pressure", but half of the excess-dose group did not have it (P = 0.041). Based on these findings, the absence of "initial stimulant pain" and the absence of "umbilical region tenderness on pressure" may predict increasing or excess use of rhubarb, and long-term use of rhubarb should be discouraged more strongly in the patients without these signs.
• POZHARSKIJ A. F.; SUSLOV A. N.; STARSHIKOV N. M.; POPOVA L. L.; KLYUEV N.+, ZH. ORGAN. XIMII, 1980, 16, HO 10, 2216-2228
  作者：POZHARSKIJ A. F.、 SUSLOV A. N.、 STARSHIKOV N. M.、 POPOVA L. L.、 KLYUEV N.+

  DOI：——

  日期：——