5-(cyclopropylamino)-7-[4-(2-hydroxyethyl)phenyl]-3-methyl-3H,4H-pyrido[4,3-d]pyrimidin-4-one | 1263072-62-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-(cyclopropylamino)-7-[4-(2-hydroxyethyl)phenyl]-3-methyl-3H,4H-pyrido[4,3-d]pyrimidin-4-one
• 英文别名: 5-(Cyclopropylamino)-7-[4-(2-hydroxyethyl)phenyl]-3-methylpyrido[4,3-d]pyrimidin-4-one
• CAS: 1263072-62-3
• 化学式: C₁₉H₂₀N₄O₂
• 分子量: 336.393
• InChiKey: PIMLMNAPDYKKRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  77.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS
  申请人：Che Jianwei

  公开号：US20120184526A1

  公开（公告）日：2012-07-19

  Provided herein are a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.

  本文提供了一类新型化合物，包括这些化合物的药物组成物和使用这些化合物治疗或预防与异常或非规则Syk激酶活性相关的疾病或障碍的方法。
• PYRIDO [4, 3-D]PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS
  申请人：IRM LLC

  公开号：EP2250169A1

  公开（公告）日：2010-11-17
• US8722692B2
  申请人：——

  公开号：US8722692B2

  公开（公告）日：2014-05-13
• [EN] PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIDO [4, 3-D] PYRIMIDINONE EN TANT QU'INHIBITEURS DE KINASES
  申请人：IRM LLC

  公开号：WO2009099801A1

  公开（公告）日：2009-08-13

  The invention provides a class of compounds of Formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC, IGR-IR, AIk, c-FMS, or combinations thereof.
• [EN] COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS<br/>[FR] COMPOSÉS ET COMPOSITIONS POUVANT SERVIR D'INHIBITEURS DE LA KINASE SYK
  申请人：IRM LLC

  公开号：WO2011014795A2

  公开（公告）日：2011-02-03

  Provided herein area novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.