Methyltetrachlornicotinat | 35592-30-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Methyltetrachlornicotinat
• 英文别名: tetrachloro-nicotinic acid methyl ester；Methyl 2,4,5,6-tetrachloropyridine-3-carboxylate
• CAS: 35592-30-4
• 化学式: C₇H₃Cl₄NO₂
• 分子量: 274.918
• InChiKey: PEEOMYFVUFSYLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• EP1689406A4
  申请人：——

  公开号：EP1689406A4

  公开（公告）日：2007-01-17
• HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF
  申请人：Array Biopharma, Inc.

  公开号：EP1689406A2

  公开（公告）日：2006-08-16
• [EN] HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF<br/>[FR] INHIBITEURS HETEROCYCLIQUES DE MEK ET METHODES D'UTILISATION ASSOCIEES
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2005051906A2

  公开（公告）日：2005-06-09

  Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X, Y and Z are as defined in the specification. Such compounds are MEK inhibitors and are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.