5β,6α-dibromocholestanol | 5034-92-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 5β,6α-dibromocholestanol
• 英文别名: 5β,6α-Dibromcholestan-3β-ol；5,6α-dibromo-5β-cholestan-3β-ol；5,6α-Dibrom-5β-cholestan-3β-ol；5.6α-Dibrom-3β-hydroxy-10.13-dimethyl-17β-((R)-1.5-dimethyl-hexyl)-5β-gonan；(10R)-5c.6t-Dibrom-3c-hydroxy-10r.13c-dimethyl-17c-((R)-1.5-dimethyl-hexyl)-(8cH.9tH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthren；5,6α-Dibrom-5β-cholestanol-(3β)；(3S,5S,6S,8S,9S,10R,13R,14S,17R)-5,6-dibromo-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-ol
• CAS: 5034-92-4
• 化学式: C₂₇H₄₆Br₂O
• 分子量: 546.47
• InChiKey: CEQDUQUVPZBDDR-YHMDZATGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5β,6α-dibromocholestanol 在 platinum(IV) oxide 氢气 、 silver fluoride 作用下， 以 四氢呋喃 为溶剂， 生成 3α-Hydroxy-5α-fluor-cholestan
  参考文献：
  名称：

  Kasal,A.; Trka,A., Collection of Czechoslovak Chemical Communications, 1974, vol. 39, p. 603 - 613

  摘要：

  DOI：
• 作为产物：
  描述：

  5α,6β-dibromocholestan-3β-ol 在 氯仿 作用下， 生成 5β,6α-dibromocholestanol
  参考文献：
  名称：

  Viruses associated with outbreaks of equine respiratory disease in New Zealand

  摘要：

  AIM: To identify viruses associated with respiratory disease in young horses in New Zealand.METHODS: Nasal swabs and blood samples were collected from 45 foals or horses from five separate outbreaks of respiratory disease that occurred in New Zealand in 1996, and from 37 yearlings at the time of the annual yearling sales in January that same year. Virus isolation from nasal swabs and peripheral blood leukocytes (PBL) was undertaken and serum samples were tested for antibodies against equine herpesviruses (EHV-1, EHV-2, EHV-4 and EHV-5), equine rhinitis-A virus (ERAV), equine rhinitis-B virus (ERBV), equine adenovirus 1 (EAdV-1), equine arteritis virus (EAV), reovirus 3 and parainfluenza virus type 3 (PIV3).RESULTS: Viruses were isolated from 24/94 (26%) nasal swab samples and from 77/80 (96%) PBL samples collected from both healthy horses and horses showing clinical signs of respiratory disease. All isolates were identified as EHV-2, EHV-4, EHV-5 or untyped EHV Of the horses and foals tested, 59/82 (72%) were positive for EHV-1 and/or EHV-4 serum neutralising (SN) antibody on at least one sampling occasion, 52/82 (63%) for EHV-1-specific antibody tested by enzyme-linked immunosorbent assay (ELISA), 10/80 (13%) for ERAV SN antibody, 60/80 (75%) for ERBV SN antibody, and 42/80 (53%) for haemagglutination inhibition (HI) antibody to EAdV-1. None of the 64 serum samples tested were positive for antibodies to EAV, reovirus 3 or PIV3. Evidence of infection with all viruses tested was detected in both healthy horses and in horses showing clinical signs of respiratory disease. Recent EHV 2 infection was associated with the development of signs of respiratory disease among yearlings [relative risk (RR) = 2.67, 95% CI = 1.59-4.47, p = 0.0171].CONCLUSIONS: Of the equine respiratory viruses detected in horses in New Zealand during this study, EHV 2 was most likely to be associated with respiratory disease. However, factors other than viral infection are probably important in the development of clinical signs of disease.

  DOI：

  10.1080/00480169.2002.36299

文献信息

• Mechanismus der Mutarotation von 5,6-Dibromcholestan
  作者：C. A. Grob、S. Winstein

  DOI：10.1002/hlca.19520350315

  日期：1952.5.2

  The mutarotation of 5 α, 6 β-dibromocholestane in a series of solvents and that of cholesterol dibromide in chloroform has been studied polarimetrically. The rate of mutarotation is quite insensitive to the addition of hydrogen bromide, benzoyl peroxide or catechol, the kineties being well formulated by reversible first order reactions.

  极化法研究了5α，6β-二溴胆甾烷在一系列溶剂中的诱变和胆固醇二溴化物在氯仿中的诱变。突变的速率对添加溴化氢，过氧化苯甲酰或邻苯二酚非常不敏感，通过可逆的一级反应可以很好地配制这些动力学。
• Momose, Den-ichi; Iguchi, Kazuo; Sugiyama, Toshikazu, Chemical and pharmaceutical bulletin, 1984, vol. 32, # 5, p. 1840 - 1853
  作者：Momose, Den-ichi、Iguchi, Kazuo、Sugiyama, Toshikazu、Yamada, Yasuji

  DOI：——

  日期：——
• The Stereochemical Course of the Addition of Halogens to Cholesterol
  作者：J. B. Ziegler、A. C. Shabica

  DOI：10.1021/ja01139a047

  日期：1952.10
• Maas; de Heus, Recueil des Travaux Chimiques des Pays-Bas, 1958, vol. 77, p. 531,534
  作者：Maas、de Heus

  DOI：——

  日期：——