1,1,4,4-tetrachloro-1,2,3,4-tetrahydrophenazine | 99979-41-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1,1,4,4-tetrachloro-1,2,3,4-tetrahydrophenazine
• 英文别名: 1,1,4,4-tetrachloro-1,2,3,4-tetrahydro-phenazine；1,1,4,4-Tetrachlor-1,2,3,4-tetrahydro-phenazin；1,1,4,4-Tetrachloro-2,3-dihydrophenazine
• CAS: 99979-41-6
• 化学式: C₁₂H₈Cl₄N₂
• 分子量: 322.021
• InChiKey: QECUSTKDLCOJPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,1,4,4-tetrachloro-1,2,3,4-tetrahydrophenazine 在 吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 1,4-dichlorophenazine
  参考文献：
  名称：

  One-Pot Synthesis of 1,4-Dichlorophenazines

  摘要：

  An efficient, generally applicable one-pot method for the synthesis of 1,4-dichlorophenazines has been established. The method is based on the use of 3,3,6,6-tetrachloro-1,2-cyclohexanedione 2 as a synthetic equivalent of 3,6-dichloro-1,2-benzoquinone 1. The reaction of 2 with primary 1,2-arylidenediamines followed by treatment with pyridine provides the title compounds in nearly quantitative yields. 1,1,4,4-Tetrachloro-1,2,3,4-tetrahydrophenazines are isolable intermediates. The crystallographic X-ray structure of 7,7'-Bis(1,1,4,4-tetrachloro-1,2,3,4-tetrahydrophenazine) 7 has been determined. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00275-5
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 1,1,4,4-tetrachloro-1,2,3,4-tetrahydrophenazine
  参考文献：
  名称：

  Sucrow; Wanzlick, Chemische Berichte, 1959, vol. 92, p. 2516,2519

  摘要：

  DOI：

文献信息

• One-Pot Synthesis of 1,4-Dichlorophenazines
  作者：Antonio Guirado、Alfredo Cerezo、M.Carmen Ramírez de Arellano

  DOI：10.1016/s0040-4020(97)00275-5

  日期：1997.4

  An efficient, generally applicable one-pot method for the synthesis of 1,4-dichlorophenazines has been established. The method is based on the use of 3,3,6,6-tetrachloro-1,2-cyclohexanedione 2 as a synthetic equivalent of 3,6-dichloro-1,2-benzoquinone 1. The reaction of 2 with primary 1,2-arylidenediamines followed by treatment with pyridine provides the title compounds in nearly quantitative yields. 1,1,4,4-Tetrachloro-1,2,3,4-tetrahydrophenazines are isolable intermediates. The crystallographic X-ray structure of 7,7'-Bis(1,1,4,4-tetrachloro-1,2,3,4-tetrahydrophenazine) 7 has been determined. (C) 1997 Elsevier Science Ltd.
• Sucrow; Wanzlick, Chemische Berichte, 1959, vol. 92, p. 2516,2519
  作者：Sucrow、Wanzlick

  DOI：——

  日期：——