1-(1,2,3,4-tetrahydro-6,7-dimethoxynaphthalen-2-yl)-N-(3,4-dimethoxyphenyl)-4-piperidinamine | 181481-37-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1-(1,2,3,4-tetrahydro-6,7-dimethoxynaphthalen-2-yl)-N-(3,4-dimethoxyphenyl)-4-piperidinamine
• 英文别名: N-(3,4-dimethoxyphenyl)-1-(6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-yl)piperidin-4-amine
• CAS: 181481-37-8
• 化学式: C₂₅H₃₄N₂O₄
• 分子量: 426.556
• InChiKey: LRBIZBLAZJFAPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  52.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-硝基苯甲酰氯 、 1-(1,2,3,4-tetrahydro-6,7-dimethoxynaphthalen-2-yl)-N-(3,4-dimethoxyphenyl)-4-piperidinamine 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以59%的产率得到N-(3,4-Dimethoxy-phenyl)-N-[1-(6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-piperidin-4-yl]-4-nitro-benzamide
  参考文献：
  名称：

  Synthesis, electrophysiological properties and analysis of structural requirements of a novel class of antiarrhythmic agents with potassium and calcium channel blocking properties

  摘要：

  Class III antiarrhythmic agents have been shown to prevent reentrant arrhythmias but also to be responsible for initiating arrhythmias characterised by afterdepolarizations and triggered activities. By combining potassium and calcium channel antagonistic actions, as with BRL-32872(1,2) (1), it might be possible to reduce the incidence of proarrhythmias albeit retaining antiarrhythmic efficacy. In the present study we synthesised and tested for their electrophysiological activity in guinea pig papillary muscle a wide panel of analogues of BRL-32872. Some qualitative relationships between compound structure and the inhibitory effect on the rapidly activating component of the delayed rectifier potassium current and/or the L-type calcium current will be presented. New derivatives depicting bell-shaped dose-response curves on action potential duration may therefore represent novel agents for improved antiarrhythmic therapy. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00166-7
• 作为产物：
  描述：

  8-(1,2,3,4-tetrahydro-6,7-dimethoxynaphthalen-2-yl)-1,4-dioxa-8-azaspiro<4,5>decane 在 盐酸 、 sodium tetrahydroborate 、 对甲苯磺酸 作用下， 反应 6.0h， 生成 1-(1,2,3,4-tetrahydro-6,7-dimethoxynaphthalen-2-yl)-N-(3,4-dimethoxyphenyl)-4-piperidinamine
  参考文献：
  名称：

  Synthesis, electrophysiological properties and analysis of structural requirements of a novel class of antiarrhythmic agents with potassium and calcium channel blocking properties

  摘要：

  Class III antiarrhythmic agents have been shown to prevent reentrant arrhythmias but also to be responsible for initiating arrhythmias characterised by afterdepolarizations and triggered activities. By combining potassium and calcium channel antagonistic actions, as with BRL-32872(1,2) (1), it might be possible to reduce the incidence of proarrhythmias albeit retaining antiarrhythmic efficacy. In the present study we synthesised and tested for their electrophysiological activity in guinea pig papillary muscle a wide panel of analogues of BRL-32872. Some qualitative relationships between compound structure and the inhibitory effect on the rapidly activating component of the delayed rectifier potassium current and/or the L-type calcium current will be presented. New derivatives depicting bell-shaped dose-response curves on action potential duration may therefore represent novel agents for improved antiarrhythmic therapy. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00166-7