4-二丙基氨基-1-丁醇 | 70289-17-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 4-二丙基氨基-1-丁醇
• 英文名称: 4-(dipropylamino)-1-butanol
• 英文别名: 4-dipropylamino-butan-1-ol；4-(N,N-DIPROPYLAMINO)BUTANOL；4-dipropylamino-1-butanol；4-Dipropylamino-butanol-(1)；1-Butanol, 4-dipropylamino-；4-(dipropylamino)butan-1-ol
• CAS: 70289-17-7
• 化学式: C₁₀H₂₃NO
• 分子量: 173.299
• InChiKey: KYNWWRBJIBSVBX-UHFFFAOYSA-N

物化性质

• 沸点：
  114 °C(Press: 4.3 Torr)
• 密度：
  0.8723 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-二丙基氨基-1-丁醇 在 氢溴酸 作用下， 生成 4-Dipropylamino-butylbromid
  参考文献：
  名称：

  Sen,A.B.; Singh,P.R., Journal of the Indian Chemical Society, 1960, vol. 37, # 4, p. 217 - 222

  摘要：

  DOI：
• 作为产物：
  描述：

  Bernsteinsaeure-dipropylamid-methylester; N,N-Dipropyl-succinamidsaeure-methylester 在 lithium aluminium tetrahydride 作用下， 生成 4-二丙基氨基-1-丁醇
  参考文献：
  名称：

  US2877265

  摘要：

  公开号：

文献信息

• Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs
  申请人：SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED

  公开号：EP0289262A3

  公开（公告）日：1989-05-31

  Quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal anti-inflammatory drugs (NSAIDs) are disclosed. These esters and thioesters display the anti-­inflammatory profile of the parent NSAIDs with greatly reduced gastrointestinal irritancy, providing a more favorable separation of therapeutic activity and toxicological side effects than the parent NSAIDs.

  披露了酸性非甾体抗炎药（NSAIDs）的四价铵烷基酯和硫酯。这些酯和硫酯显示出与原始NSAIDs相同的抗炎特性，但胃肠刺激性大大降低，提供了比原始NSAIDs更有利的治疗活性和毒理副作用之间的分离。
• A virtual screening approach to identifying the greenest compound for a task: application to switchable-hydrophilicity solvents
  作者：J. R. Vanderveen、L. Patiny、C. B. Chalifoux、M. J. Jessop、P. G. Jessop

  DOI：10.1039/c5gc01022e

  日期：——

  QSAR-based virtual screening makes it easier to identify lead structures that could simultaneously satisfy several performance criteria and several green criteria.

  基于QSAR的虚拟筛选使得更容易识别出能够同时满足多个性能标准和多个绿色标准的先导结构。
• PREPARATION OF N,N-(DI)ALKYLAMINOALKYL(METH)ACRYLAMIDE OR N,N-(DI)ALKYLAMINOALKYL (METH)ACRYLATE AND THE QUATERNARY AMMONIUM SALTS THEREOF AS FLOCCULATING AIDS AND GELLING AGENTS
  申请人：Evonik Roehm GmbH

  公开号：US20170369424A1

  公开（公告）日：2017-12-28

  N,N-(di)alkylaminoalkyl(meth)acrylamide or N,N-(di)alkylaminoalkyl (meth)acrylate and/or a quaternary ammonium salt thereof are prepared with a low content of a compound of formula (IV) wherein R 5 in each case is a linear, branched or cyclic alkyl radical, an aryl radical which may also be substituted by one or more alkyl groups, the linear, cyclic or branched alkyl radical may have a length of 1-12 carbon atoms and is, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, hexyl, heptyl, octyl, isooctyl, nonyl, decyl, undecyl, dodecyl.

  制备低含量的化合物公式（IV）其中R5在每种情况下都是线性，支链或环烷基，芳基，也可以被一个或多个烷基取代，线性，环状或支链烷基长度可以为1-12个碳原子，例如甲基，乙基，丙基，异丙基，丁基，异丁基，叔丁基，戊基，己基，庚基，异辛基，壬基，癸基。制备N，N-（二）烷基氨基烷基（甲基）丙烯酰胺或N，N-（二）烷基氨基烷基（甲基）丙烯酸酯和/或其季铵盐。
• [EN] QUATERNARY AMMONIUM COMPOUNDS AND THEIR USE AS FUEL OR LUBRICANT ADDITIVES<br/>[FR] COMPOSÉS D'AMMONIUM QUATERNAIRE ET LEUR UTILISATION EN TANT QU'ADDITIFS DE CARBURANT OU DE LUBRIFIANT
  申请人：INNOSPEC LTD

  公开号：WO2016016641A1

  公开（公告）日：2016-02-04

  A quaternary ammonium salt of formula wherein each of R1, R2, R3 and R4 is independently selected from an optionally substituted alkyl, alkenyl or aryl group having less than 8 carbon atoms and R5 is hydrogen or an optionally substituted hydrocarbyl group.

  一种四元铵盐，其化学式为其中R1，R2，R3和R4各自独立地选自不超过8个碳原子的可选择取代的烷基，烯基或芳基，而R5是氢或可选择取代的烃基。
• Amine compounds and use thereof
  申请人：Yamazaki Toru

  公开号：US20050165063A1

  公开（公告）日：2005-07-28

  It is intended to provide novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism and cancer metastasis. Namely, amine compounds represented by the following general formula (1): In a typical case, A1 and A2 represent each an optionally substituted monocyclic or polycyclic aromatic heterocycle; W represents cyclic C3-10 alkylene, an optionally substituted monocyclic or polycyclic aromatic heterocycle, a monocyclic or polycyclic aromatic ring or a partly saturated polycyclic aromatic ring; X represents O, CH2, C(═O) or NR11; and D is a group represented by the following general formula (4) or (6). In the formula (6), Q represents a single bond, S, O or NR12; and Y is a group represented by the following general formula (7). z represents an optionally substituted monocyclic or polycyclic aromatic ring. In the formula (6), B represents NR25R26. In the above formulae, R1 to R26 each represents hydrogen, alkyl, alkenyl or alkynyl.

  本发明旨在提供新型胺化合物，其对感染HIV病毒、风湿病和癌症转移等疾病具有疗效。即以下通式（1）所代表的胺化合物：在典型情况下，A1和A2分别代表可选择取代的单环或多环芳香杂环；W代表环状C3-10烷基，可选择取代的单环或多环芳香杂环，单环或多环芳香环或部分饱和多环芳香环；X代表O，CH2，C（═O）或NR11；D是以下通式（4）或（6）所代表的基团。在公式（6）中，Q代表单键，S，O或NR12；Y代表以下通式（7）所代表的基团。z代表可选择取代的单环或多环芳香环。在公式（6）中，B代表NR25R26。在上述公式中，R1至R26每个代表氢，烷基，烯基或炔基。

表征谱图