(1H-inden-2-yl)diphenylphosphine | 857444-03-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: (1H-inden-2-yl)diphenylphosphine
• 英文别名: 2-(Diphenylphosphino)indene；1H-inden-2-yl(diphenyl)phosphane
• CAS: 857444-03-2
• 化学式: C₂₁H₁₇P
• 分子量: 300.34
• InChiKey: LIDLECDACSRQDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (1H-inden-2-yl)diphenylphosphine 、 (苯乙炔基)金 以 二氯甲烷 为溶剂， 反应 2.0h， 以61%的产率得到
  参考文献：
  名称：

  Synthesis and Molecular Recognition Studies on Small-Molecule Inhibitors for Thioredoxin Reductase

  摘要：

  Thioredoxiin reductase (TrxR), which is overex pressed in many aggressive cancers, plays a crucial role in redox balance and antioxidant function, including defense of oxidative stress, control of cell proliferation, and regulation of cell apoptosis. Deactivation of TrxR can destroy the homeostatis of the cancer cells, inducing elevation of reactive oxygen species (ROS) levels and the oxidation of enzymatic substrates Here we synthesized and identified a new gold(I) small molecule (D9) that processes two strong electron-donating moieties i.e., 4-methylphenyl alkynyl and thionyldiphenyl phosephine exhibiting an enhanced p-pi conjuction effect. The resulting compound shows the increased soft Lewis-acids and the stability of gold(I) And we demonstrated that D9 could efficiently and specifically inhibit the activity of TrxR in vitro and in vivo, and it could effectively avoid the ligand exchange with albumin that was one of the mose abundant proteins in blood. We believe that these comprehensive studies on the relationship between the structure and performance will provide inspiring information on the precise synthesis and design of new compounds for targeting TrxR.

  DOI：

  10.1021/jm5012098

文献信息

• Phosphorus substituted metallocene compounds for olefin polymerization
  申请人：Voskoboynikov Z. Alexander

  公开号：US20050239980A1

  公开（公告）日：2005-10-27

  This invention relates to a metallocene compounds represented by formula: wherein M is a group 3, 4, 5 or 6 transition metal atom, or a lanthanide metal atom, or actinide metal atom; E is an indenyl ligand that is substituted with a PR 2 group in the two position of the indenyl ligand, where each R is, independently a hydrocarbyl, substituted hydrocarbyl, halocarbyl, or substituted halocarbyl substituent, and additionally, E may be substituted with 0, 1, 2, 3, 4, 5 or 6 R n where each R n is, independently, a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituent, and optionally, two or more adjacent R n substituents may join together to form a substituted or unsubstituted, saturated, partially unsaturated, or aromatic cyclic or polycyclic substituent; A is a substituted or unsubstituted cyclopentadienyl ligand, a substituted or unsubstituted heterocyclopentadienyl ligand, a substituted or unsubstituted indenyl ligand, a substituted or unsubstituted heteroindenyl ligand, a substituted or unsubstituted fluorenyl ligand, a substituted or unsubstituted heterofluorenyl ligand, or other mono-anionic ligand, or A may, independently, be defined as E or as X; each X is, independently, an univalent anionic ligand, or both X are joined and bound to the metal atom to form a metallocycle ring, or both X join to form a chelating ligand, a diene ligand, or an alkylidene ligand.

  本发明涉及一种由以下公式表示的金属茂化合物：其中M是3、4、5或6族过渡金属原子、镧系金属原子或锕系金属原子；E是一个在茂环的2位被PR2基取代的茚烯配体，其中每个R都是独立的，可以是一个碳氢化合物、取代的碳氢化合物、卤代碳氢化合物或取代的卤代碳氢化合物基团，此外，E可以被0、1、2、3、4、5或6个Rn取代，其中每个Rn都是独立的，可以是一个碳氢化合物、取代的碳氢化合物、卤代碳氢化合物、取代的卤代碳氢化合物、硅基碳氢化合物、取代的硅基碳氢化合物、锗基碳氢化合物或取代的锗基碳氢化合物基团，而且，两个或更多相邻的Rn取代基团可以结合在一起形成取代或未取代的饱和、部分不饱和或芳香环或多环取代基团；A是一个取代或未取代的环戊二烯基配体、取代或未取代的杂环戊二烯基配体、取代或未取代的茚烯配体、取代或未取代的杂茚烯配体、取代或未取代的芴基配体、取代或未取代的杂芴基配体或其他单阴离子配体，或者A可以独立地被定义为E或X；每个X都是独立的一价阴离子配体，或者两个X结合并与金属原子结合形成金属环烷基，或两个X结合形成螯合配体、二烯配体或烷基亚胺配体。
• Zirconium Complexes Involving 2-Phosphorus-Substituted Indenyl Fragments
  作者：Denis N. Kazul'kin、Alexey N. Ryabov、Vyatcheslav V. Izmer、Andrei V. Churakov、Irina P. Beletskaya、Carol J. Burns、Alexander Z. Voskoboynikov

  DOI：10.1021/om050236h

  日期：2005.6.1

  Ni-catalyzed Arbuzov reaction of 2-bromo-1H-indene with P(OEt)3, was found to be a convenient starting material for the synthesis of 2-H2P-substituted indene. 1H-Inden-2-yl(phenyl)phosphine, prepared via the Pd-catalyzed arylation of 2-H2P-substituted indene by PhI, turned out to react with 2-bromo-1H-indene in the presence of Pd(PPh3)4 and Et3N to form di(1H-inden-2-yl)(phenyl)phosphine in almost

  一系列2-R 2 P取代的茚基，其中R 2 P = Ph 2 P，Cy 2 P，iPr 2 P和tBu（H）P是通过Pd催化2-溴1 H-茚（或1 H-茚-2-基三氟甲烷磺酸盐）与R 2 PH / Et 3 N的反应而得到的。类似于Me 2 P的茚，ŤBu（Cl）P和t通过1 H-茚-2-基二氯化磷与MeLi，t的反应获得2位的Bu 2 P取代基BuMgCl和t氯化镁/吨BuLi-CuCN，分别。通过2-溴-1 H-茚与P（OEt）3的Ni催化Arbuzov反应制备的1 H-茚-2-基膦酸二乙酯被发现是合成2-H 2的方便原料。对取代的茚。1 ħ茚-2-基（苯基）膦，通过2-H的Pd催化的芳基化制备2由是Phl P-取代的茚，原来用2-溴-1-反应ħ在钯的存在下-茚（PPh 3）4和Et 3 N以几乎定量的产率形成二（1 H-茚满-2-基）（苯基）膦。类似地，二（1 H-茚满-2-基）（叔
• Trinuclear and Tetranuclear Ruthenium Carbonyl Clusters Derived from Indenylphosphines: Cleavage of C−H and C−P Bonds
  作者：Xing Tan、Bin Li、Shansheng Xu、Haibin Song、Baiquan Wang

  DOI：10.1021/om200072g

  日期：2011.4.25

  of Ru3(CO)12 with (4,7-dimethyl-1H-inden-3-yl)diphenylphosphine in octane gave trinuclear ruthenium cluster Ru3(μ2-H)(μ3-3-Ph2PC11H10)(CO)9 (5) via a C−H bond cleavage. Heating 5 in octane afforded a trinuclear ruthenium cluster Ru3(μ3-PPh)(μ3-C11H10)(CO)9 (6) and two isomeric tetranuclear ruthenium clusters Ru4(μ3-PPh)(μ2-η5:η1-C11H10)(CO)11 (7) and [Ru4(μ4-PPh)(μ4-C11H10)(CO)11] (8) via double C−P

  茹的热处理3（CO）12与等摩尔量（1 ħ茚-3-基）二苯基膦和（1 ħ茚-2-基）辛烷二苯基膦，得到两种异构体的三核钌簇的Ru 3（μ 2 - H）（μ 3 -3-PH 2 PC 9 ħ 6）（CO）9（1）和Ru 3（μ 2 -H）（μ 3 -2-PH 2 PC 9 ħ 6）（CO）9（2）分别通过CH键断裂。加热1或2中辛烷，得到三核和四核钌簇的Ru 3（μ 3 -PPh）（μ 3 -C 9 ħ 6）（CO）9（3）和Ru 4（μ 4 -PPh）（μ 4 -C 9 H 6）（CO）11（4）通过双C-P键断裂。茹的热处理3（CO）12与（4,7-二甲基-1- ħ在辛烷茚-3-基）二苯基膦，得到三核钌簇的Ru 3（μ 2 -H）（μ 3-3-Ph 2 PC 11 H 10）（CO）9（5）通过CH键断裂。加热5在辛烷，得到三核钌簇的Ru 3（μ 3 -PPh）（μ 3 -C 11 ħ
• PHOSPHORUS SUBSTITUTED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION
  申请人：ExxonMobil Chemical Patents, Inc.

  公开号：EP1737875A1

  公开（公告）日：2007-01-03
• US7214747B2
  申请人：——

  公开号：US7214747B2

  公开（公告）日：2007-05-08