碳酸-N,N,N-三乙基乙铵酯(2:1) | 52724-28-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 碳酸-N,N,N-三乙基乙铵酯(2:1)
• 中文别名: 碳酸-N,N,N-三乙基乙铵酯
• 英文名称: Tetraethylammonium carbonate
• 英文别名: tetraethylazanium;carbonate
• CAS: 52724-28-4
• 化学式: C17H40N2O3
• 分子量: 320.5
• InChiKey: APBDREXAUGXCCV-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  1.32
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38

反应信息

• 作为反应物：
  描述：

  9-溴甲基丫啶 、 辛酸 、 碳酸-N,N,N-三乙基乙铵酯(2:1) 生成 acridin-9-ylmethyl octanoate
  参考文献：
  名称：

  AKASAKA, KAZUAKI;SUZUKI, TATEO;OHRUI, HIROSHI;MEGURO, HIROSHI;SHINDO, YOS+, ANAL. LETT., 20,(1987) N 10, 1581-1594

  摘要：

  DOI：
• 作为产物：
  描述：

  四乙基溴化铵 、 二氧化碳 生成 碳酸-N,N,N-三乙基乙铵酯(2:1)
  参考文献：
  名称：

  AKASAKA, KAZUAKI;SUZUKI, TATEO;OHRUI, HIROSHI;MEGURO, HIROSHI;SHINDO, YOS+, ANAL. LETT., 20,(1987) N 10, 1581-1594

  摘要：

  DOI：

文献信息

• Process for preparing 4-aminodiphenylamine
  申请人：Wang Nongyue

  公开号：US20050065376A1

  公开（公告）日：2005-03-24

  The present invention discloses a process for preparing 4-aminodiphenylamine, which process uses nitrobenzene and aniline as raw materials, a complex base catalyst as condensation catalyst and a powdery composite catalyst as hydrogenation catalyst, and comprises five process stages: condensation; separation I; hydrogenation; separation II; and refining. The process can be continuously carried out. By selecting a complex base catalyst to catalyze the condensation reaction and separating it prior to the hydrogenation, the problem that the complex base catalysts thermally decompose in the hydrogenation reaction is avoided, the selectable range of hydrogenation catalysts is largely enlarged so that it is possible to select cheaper hydrogenation catalyst, and the selection of production process and equipment is easier and further industrialization is easier. The complex base catalysts used in the present invention are inexpensive and have higher catalytic activity. The process can be carried out at mild conditions and can adapt to broad range of water content, by-product is less and conversion and selectivity are higher. The operational strength is low, no corrosive liquid is produced, and environment pollution is reduced. The purity of 4-aminodiphenylamine prepared can exceed 99 wt.-%, and the yield in the industrial production process can be over 95%.

  本发明公开了一种制备4-氨基二苯胺的方法，该方法使用硝基苯和苯胺作为原料，复合碱基催化剂作为缩合催化剂，粉状复合催化剂作为加氢催化剂，并包括五个工艺阶段：缩合；分离I；加氢；分离II；和精制。该方法可以连续进行。通过选择复合碱基催化剂催化缩合反应并在加氢之前分离它，避免了复合碱基催化剂在加氢反应中热分解的问题，大大扩大了可选择的加氢催化剂范围，从而可以选择更便宜的加氢催化剂，并且生产工艺和设备的选择更容易，进一步工业化更容易。本发明中使用的复合碱基催化剂价格低廉且具有较高的催化活性。该方法可以在温和条件下进行，并且可以适应广泛的含水量范围，副产物较少，转化率和选择性较高。操作强度低，不产生腐蚀性液体，减少了环境污染。制备的4-氨基二苯胺的纯度可以超过99重量％，工业生产过程中的产率可以超过95％。
• POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC M2 RECEPTOR
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：US20180297994A1

  公开（公告）日：2018-10-18

  The present application relates to positive allosteric modulators of the muscarinic M2 receptor, especially to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular disorders and/or renal disorders.

  本申请涉及肌动蛋白M2受体的阳性变构调节剂，特别是新型的7-取代的1-芳基萘啶-3-羧酰胺，以及其制备方法，单独或组合使用于治疗和/或预防疾病，以及用于生产治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病和/或肾脏疾病。
• [EN] PREPARATION OF FLUOROSULFONATE ESTERS AND ONIUM SALTS DERIVED THEREFROM<br/>[FR] PRÉPARATION D'ESTERS DE FLUOROSULFONATE ET SELS D'ONIUM DÉRIVÉS DE CEUX-CI
  申请人：TRINAPCO INC

  公开号：WO2014124456A1

  公开（公告）日：2014-08-14

  The present invention is directed to methods for preparing a fluorosulfonate ester or a salt thereof, through a reaction of a dissolved sulfonyl fluoride (RFSO2F) with alkoxide anion (RO- ) optionally in the presence of an aprotic base (B), where RF is fluorine or a C1-C8 perfluoroalkyl group, and R is a primary alkyl or alkoxyalkyl. Alkoxide anion (RO-) can be generated from a precursor such as an alcohol or silyl ester.

  本发明涉及通过将溶解的磺酰氟化物（RFSO2F）与烷氧基阴离子（RO-）在有无无水碱（B）的情况下反应，制备氟磺酸酯或其盐的方法，其中RF为氟或C1-C8全氟烷基基团，R为一次烷基或烷氧基烷基。烷氧基阴离子（RO-）可以由醇或硅酯等前体生成。
• HETEROCYCLIC COMPOUND AS PROTEIN KINASE INHIBITOR
  申请人：Kim Tae-Seong

  公开号：US20110183983A1

  公开（公告）日：2011-07-28

  Provided are novel heterocyclic compounds useful as anti-cancer drugs by suppressing protein kinase activities of growth factor receptors such as c-Met, pharmaceutical compositions containing the same, and methods for using the compound.

  提供了一种新型杂环化合物，通过抑制c-Met等生长因子受体的蛋白激酶活性，可用作抗癌药物，还包括含有这种化合物的药物组合物，以及使用该化合物的方法。
• [EN] ALKYNYL ALCOHOLS AS KINASE INHIBITORS<br/>[FR] ALCOOLS D'ALCYNYLE UTILISÉS COMME INHIBITEURS DE KINASES
  申请人：AMGEN INC

  公开号：WO2009158011A1

  公开（公告）日：2009-12-30

  Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like.

  选定的化合物对预防和治疗炎症和炎症性疾病，如NIK介导的疾病，具有有效性。该发明涵盖了新颖的化合物、类似物、前药及其药用可接受的盐，以及用于预防和治疗涉及炎症等疾病和其他疾病或病症的药物组合物和方法。