2-Ethyl-2-hydroxysuccinimid | 58467-28-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-Ethyl-2-hydroxysuccinimid
• 英文别名: 2-Hydroxy-2-ethyl-succinimid；3-ethyl-3-hydroxy-pyrrolidine-2,5-dione；3-Ethyl-3-hydroxy-2,5-pyrrolidinedione；3-ethyl-3-hydroxypyrrolidine-2,5-dione
• CAS: 58467-28-0
• 化学式: C₆H₉NO₃
• 分子量: 143.142
• InChiKey: RPCTYNXSSJMSMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• MODIFICATION OF ALLERGENS FOR IMMUNOTHERAPY
  申请人：Hal Allergy Holding B.V.

  公开号：EP2318045A1

  公开（公告）日：2011-05-11
• US6589510B2
  申请人：——

  公开号：US6589510B2

  公开（公告）日：2003-07-08
• [EN] MODIFICATION OF ALLERGENS FOR IMMUNOTHERAPY<br/>[FR] MODIFICATION D'ALLERGÈNES POUR L'IMMUNOTHÉRAPIE
  申请人：HAL ALLERGY HOLDING B V

  公开号：WO2010000873A1

  公开（公告）日：2010-01-07

  The present invention relates to pharmaceutical compositions for immunotherapy, for example for immunotherapy of peanut allergy. Further, the present invention relates to methods for the preparation of the present pharmaceutical compositions for immunotherapy, and their use in immunotherapy. Furthermore, the present invention relates to processes for modifying allergens thereby enhancing their application in immunotherapy. The invention also relates to the present modified allergens and pharmaceutical compositions comprising the present allergens, as well as to the use thereof in immunotherapy. According to a particularly preferred embodiment, the present invention relates to pharmaceutical compositions for immunotherapy comprising reduced and alkylated naturally occurring peanut allergens Ara h2 and/or Ara h6, or derivates or isoforms thereof wherein said pharmaceutical composition substantially does not comprise Ara h1 and/or Ara h3.