(S)-1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-(2-hydroxy-3-methylbutyl)urea | 1455032-09-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (S)-1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-(2-hydroxy-3-methylbutyl)urea
• 英文别名: 1-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-3-[(2S)-2-hydroxy-3-methylbutyl]urea
• CAS: 1455032-09-3
• 化学式: C₂₃H₂₈FN₅O₂
• 分子量: 425.506
• InChiKey: KLQDELLXVSIUSF-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  99.2
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• [EN] RAF INHIBITOR COMPOUNDS<br/>[FR] COMPOSÉS INHIBITEURS DE RAF
  申请人：DECIPHERA PHARMACEUTICALS LLC

  公开号：WO2013134298A1

  公开（公告）日：2013-09-12

  This invention provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I); and use of a compound of Formula (I) for treating specified cancers.

  这项发明提供了化合物的公式(I)或其药用可接受的盐；包括公式(I)化合物的药物组合物；以及使用公式(I)化合物治疗特定癌症。
• [EN] NOVEL SUBSTITUTED ISOTHIAZOLOPYRIDONES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND/OR PLANT GROWTH REGULATORS<br/>[FR] NOUVELLES ISOTHIAZOLOPYRIDONES SUBSTITUÉES, LEURS PROCÉDÉS DE PRÉPARATION ET LEUR UTILISATION EN TANT QU'HERBICIDES ET/OU QUE RÉGULATEURS DE CROISSANCE DES PLANTES
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2019007795A1

  公开（公告）日：2019-01-10

  The invention relates to the technical field of the herbicides and/or plant growth regulators. Specifically, the invention primarily relates to novel substituted isothiazolopyridones, and compositions comprising said novel substituted isothiazolopyridones. Further, the present invention relates to processes for the preparation said novel substituted isothiazolopyridones and their use as herbicides and/or plant growth regulators.

  该发明涉及除草剂和/或植物生长调节剂的技术领域。具体来说，该发明主要涉及新型取代异噻唑吡啶酮，以及包含该新型取代异噻唑吡啶酮的组合物。此外，本发明涉及制备该新型取代异噻唑吡啶酮的方法及其用作除草剂和/或植物生长调节剂的用途。
• [EN] NOVEL ISOTHIAZOLO-BASED BICYCLES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND/OR PLANT GROWTH REGULATORS<br/>[FR] NOUVEAUX BICYCLES À BASE ISOTHIAZOLO, LEURS PROCÉDÉS DE PRÉPARATION ET LEUR UTILISATION EN TANT QU'HERBICIDES ET/OU RÉGULATEURS DE CROISSANCE DES PLANTES
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2019007793A1

  公开（公告）日：2019-01-10

  The invention relates to the technical field of herbicides and/or plant growth regulators. Specifically, the invention relates to novel isothiazolo-based bicycles, and compositions comprising said novel isothiazolo-based bicycles. Further, the present invention relates to processes for the preparation said novel isothiazolo-based bicycles and their use as herbicides and/or plant growth regulators.

  本发明涉及除草剂和/或植物生长调节剂的技术领域。具体而言，本发明涉及新型异噻唑基自行车和包含所述新型异噻唑基自行车的组合物。此外，本发明还涉及制备所述新型异噻唑基自行车的过程以及它们作为除草剂和/或植物生长调节剂的用途。
• RAF INHIBITOR COMPOUNDS
  申请人：Deciphera Pharmaceuticals, LLC

  公开号：US20150105367A1

  公开（公告）日：2015-04-16

  This invention provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I); and use of a compound of Formula (I) for treating specified cancers.

  该发明提供了式(I)的化合物或其药学上可接受的盐；包含式(I)化合物的制药组合物；以及使用式(I)化合物治疗特定癌症的方法。
• NEW USES OF 2-(2,4-DICHLOROPHENYL)METHYL-4,4-DIMETHYL-3-ISOXAZOLIDONE AS FOLIAR HERBICIDE
  申请人：Bayer CropScience Aktiengesellschaft

  公开号：EP3331363A1

  公开（公告）日：2018-06-13