5LIN(Me)-1,2-HOPO | 945827-75-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5LIN(Me)-1,2-HOPO
• 英文别名: 1-hydroxy-N-[2-[2-[(1-hydroxy-6-oxopyridine-2-carbonyl)amino]ethyl-methylamino]ethyl]-6-oxopyridine-2-carboxamide
• CAS: 945827-75-8
• 化学式: C₁₇H₂₁N₅O₆
• 分子量: 391.384
• InChiKey: CRWUOTHNNAPSNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  143
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  europium(III) chloride hexahydrate 、 5LIN(Me)-1,2-HOPO 、 potassium chloride 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  具有强水稳定性的八齿发光Eu（III）1,2-HOPO螯合物。

  摘要：

  两个新的配体5LINMe-1,2-HOPO（1）和H（2,2）-1,2-HOPO（2）的合成，表征和光物理性质，它们利用1,2-HOPO螯合物作为报告了一种用于Eu（III）的敏化剂。另外，通过X射线晶体学将先前的配体在结构上表征为Eu（III）络合物。四齿配体（1）的[Eu（1）2]-络合物在水溶液中稳定至约极限浓度。7x10（-9）M，并保留了1,2-HOPO敏化剂所具有的出色的光物理性能。相比之下，八齿配体（2）作为[Eu（2）]-络合物，经进一步稀释至极限浓度ca时，其稳定性大大提高。5x10（-17）M，超出大多数荧光计的最低可检测浓度。

  DOI：

  10.1021/ic700364t

文献信息

• [EN] MACROCYCLIC HOPO CHELATORS<br/>[FR] CHÉLATEURS HOPO MACROCYCLIQUES
  申请人：LUMIPHORE INC

  公开号：WO2011025790A1

  公开（公告）日：2011-03-03

  The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.

  本发明提供了一种新型的大环化合物类别，以及由金属离子（例如，镧系元素）与本发明的化合物形成的配合物。首选的配合物在水介质中表现出高稳定性，以及镧系离子的发光量子产率高，而无需辅助激活剂。首选的化合物包括其大环结构中的羟基吡啶酮基团，并以对多种多肽（如抗体和蛋白质）的非特异性结合惊人地低以及高动力学稳定性为特征。
• MACROCYCLIC HOPO CHELATORS
  申请人：Butlin Nathaniel G.

  公开号：US20120214253A1

  公开（公告）日：2012-08-23

  The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.

  本发明提供了一类新型的大环化合物，以及由金属（例如镧系金属）离子和本发明中的化合物形成的络合物。优选的络合物在无需次级活化剂的情况下，具有高稳定性和高量子产率的镧系离子荧光。优选的化合物在它们的大环结构中包括羟基吡啶酮基团，并且其特点是与各种多肽（如抗体和蛋白质）具有惊人的低非特异性结合和高动力学稳定性。
• Macrocyclic HOPO chelators
  申请人：LUMIPHORE, INC.

  公开号：US10352938B2

  公开（公告）日：2019-07-16

  The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.

  本发明提供了一类新型大环化合物以及金属（如镧系元素）离子与本发明化合物之间形成的配合物。优选的配合物在水介质中表现出高稳定性和高镧系离子发光量子产率，无需使用二级活化剂。优选化合物在其大环结构中包含羟基吡啶壬基，其特点是与抗体和蛋白质等多种多肽的非特异性结合率低得出奇，并且具有很高的动力学稳定性。
• HOPO CHELATORS
  申请人：Lumiphore, Inc.

  公开号：EP2816038B1

  公开（公告）日：2019-11-20
• US9273059B2
  申请人：——

  公开号：US9273059B2

  公开（公告）日：2016-03-01