(5,6-dimethyl-pyrimidin-4-yl)-phenyl-amine | 85073-88-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5,6-dimethyl-pyrimidin-4-yl)-phenyl-amine
• 英文别名: (5,6-Dimethyl-pyrimidin-4-yl)-phenyl-amin；5,6-dimethyl-N-phenylpyrimidin-4-amine
• CAS: 85073-88-7
• 化学式: C₁₂H₁₃N₃
• 分子量: 199.255
• InChiKey: OBKSYWXNTHJLQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氯-5,6-二甲基嘧啶 、 苯胺 生成 (5,6-dimethyl-pyrimidin-4-yl)-phenyl-amine
  参考文献：
  名称：

  Schlenker, Chemische Berichte, 1901, vol. 34, p. 2813

  摘要：

  DOI：

文献信息

• Pyrimidine derivatives, a process for preparing them and a pharmaceutical composition containing them
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0067630B1

  公开（公告）日：1985-05-08
• US4450162A
  申请人：——

  公开号：US4450162A

  公开（公告）日：1984-05-22
• [EN] METHOD FOR TREATING INFLAMMATORY CONDITIONS<br/>[FR] MÉTHODE DE TRAITEMENT D'AFFECTIONS INFLAMMATOIRES
  申请人：INSPIRE PHARMACEUTICALS INC

  公开号：WO2010080540A1

  公开（公告）日：2010-07-15

  This invention provides a method for inhibiting the release of interleukin-1β in a mammal. This invention also provides a method for preventing or treating pulmomary diseases, ophthalmic diseases, and autoimmune diseases that are associated with inflammation or inflammatory conditions. The invention also provides a method for preventing or treating neurodegenerative diseases, or pain in a mammal. The method comprises administering to a mammal in need thereof a therapeutically effective amount of a mononucleoside compound, which is an antagonist of P2X7 receptor.