3-(2-chlorophenyl)-N-methyl-N-phenylpropiolamide | 1023304-97-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(2-chlorophenyl)-N-methyl-N-phenylpropiolamide
• CAS: 1023304-97-3
• 化学式: C₁₆H₁₂ClNO
• 分子量: 269.73
• InChiKey: HINMFXFDZDHSHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.35
• 重原子数：
  19.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  20.31
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  3-(2-chlorophenyl)-N-methyl-N-phenylpropiolamide 、 溶剂黄146 在 碘苯二乙酸 、 palladium diacetate 作用下， 以77%的产率得到(E)-(2-chlorophenyl)(1-methyl-2-oxoindolin-3-ylidene)methyl acetate
  参考文献：
  名称：

  Synthesis of (2-Oxoindolin-3-ylidene)methyl Acetates Involving a C−H Functionalization Process

  摘要：

  [GRAPHICS]A novel palladium-catalyzed oxidative C-H functionalization protocol for the synthesis of (2-oxoindolin-3-ylidene)methyl acetates has been developed. In the presence of Pd(OAC)(2) and Phl(OAC)(2), a variety of N-arylpropiolamides underwent the C-H functionalization reaction with acids to afford the corresponding (E)-(2-oxoindolin-3-ylidene)methyl acetates selectively in moderate to excellent yields.

  DOI：

  10.1021/ol8006315

文献信息

• AgSCF₃-Mediated Oxidative Trifluoromethythiolation of Alkynes with Dearomatization to Synthesize SCF₃-Substituted Spiro[4,5]trienones
  作者：Dong-Po Jin、Pin Gao、Dao-Qian Chen、Si Chen、Jia Wang、Xue-Yuan Liu、Yong-Min Liang

  DOI：10.1021/acs.orglett.6b01702

  日期：2016.7.15

  A new method for the AgSCF3-mediated radical cascade difunctionalizing trifluoromethythiolation of alkynes with dearomatization is developed. This protocol provides a novel route to SCF3-substituted spirocyclic compounds via the formation of one C-SCF3 bond, one C-C bond, and one C-O double bond in a single step.