methyl-(1S,2R,3S)-1-(3,4-methylenedioxyphenyl)-3-(4-methoxy-2-hydroxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylate | 190970-28-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: methyl-(1S,2R,3S)-1-(3,4-methylenedioxyphenyl)-3-(4-methoxy-2-hydroxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylate
• 英文别名: Methyl-(1S,2R,3S)-1-(3,4-methylenedioxyphenyl)-3-(4-methoxy-2-hydroxyphenyl)-5-propoxyindane-2-carboxylate；methyl (1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-(2-hydroxy-4-methoxyphenyl)-5-propoxy-2,3-dihydro-1H-indene-2-carboxylate
• CAS: 190970-28-6
• 化学式: C₂₈H₂₈O₇
• 分子量: 476.526
• InChiKey: SXADTDRGAMTFIN-OYUWMTPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  83.4
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  methyl-(1S,2R,3S)-1-(3,4-methylenedioxyphenyl)-3-(4-methoxy-2-hydroxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylate 在 lithium hydroxide 、 柠檬酸 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 生成 (1S,2R,3S)-1-(3,4-methylenedioxyphenyl)-3-(4-methoxy-2-hydroxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid
  参考文献：
  名称：

  Stereoselective synthesis of endothelin receptor antagonists

  摘要：

  本发明涉及一种合成途径，用于制备公式（7B）和（7A）的内皮受体拮抗剂，以及手性中间体##STR1##

  公开号：

  US06080862A1

文献信息

• Process for preparing indane carboxylate and cyclopentano [6] pyridine derivatives
  申请人：SmithKline Beecham Corporation

  公开号：US06441173B1

  公开（公告）日：2002-08-27

  This invention relates to an improved process for preparing (+) (1S,2R,3S)-3-[2-(2-hydroxyeth-1-yloxy)-4-methoxyphenyl]-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof, preferably the ethylene diamine 2:1 salt. This invention relates to novel intermediates useful in preparing (+) (1S,2R,3S)-3-[2-(2-hydroxyeth-1-yloxy)-4-methoxyphenyl]-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid. This invention relates to an improved process for preparing (+) (1S,2R,3S)-3-(2-carboxymethoxy-4-methoxyphenyl)-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof, preferably the disodium salt. This invention relates to novel intermediates useful in preparing (+) (1S,2R,3S)-3-(2-carboxymethoxy-4-methoxyphenyl)-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid.

  本发明涉及一种改进的制备方法，用于制备(+) (1S,2R,3S)-3-[2-(2-羟乙基氧基)-4-甲氧基苯基]-1-(3,4-亚甲二氧基苯基)-5-(丙-1-氧基)茚-2-羧酸及其药学上可接受的盐，优选为乙二胺2:1盐。本发明涉及有用于制备(+) (1S,2R,3S)-3-[2-(2-羟乙基氧基)-4-甲氧基苯基]-1-(3,4-亚甲二氧基苯基)-5-(丙-1-氧基)茚-2-羧酸的新型中间体。本发明涉及一种改进的制备方法，用于制备(+) (1S,2R,3S)-3-(2-羧甲氧基-4-甲氧基苯基)-1-(3,4-亚甲二氧基苯基)-5-(丙-1-氧基)茚-2-羧酸及其药学上可接受的盐，优选为二钠盐。本发明涉及有用于制备(+) (1S,2R,3S)-3-(2-羧甲氧基-4-甲氧基苯基)-1-(3,4-亚甲二氧基苯基)-5-(丙-1-氧基)茚-2-羧酸的新型中间体。
• Process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic
  申请人：SmithKline Beecham Corporation

  公开号：US06114549A1

  公开（公告）日：2000-09-05

  Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentano[b]pyridine derivatives. The most preferred compounds prepared by this invention are (+)(1S, 2R, 3S)-3-[2-(2-hydroxyeth-1-yloxy)4-methoxyphenyl]-1-(3,4-methylenedioxypheny l)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof and (+)(1S, 2R, 3S)-3-(2-carboxymethoxy-4-methoxyphenyl)-1-(3,4-methylenedioxyphenyl)-5-(p rop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof. Also invented are novel intermediates useful in preparing these compounds.

  本发明提供了一种改进的制备芳香环融合环戊烷衍生物的方法。本发明制备的优选化合物为茚酸酯和环戊[b]吡啶衍生物。本发明制备的最优选化合物为(+)(1S,2R,3S)-3-[2-(2-羟乙氧基)4-甲氧基苯基]-1-(3,4-亚甲二氧基苯基)-5-(丙-1-氧基)茚并-2-羧酸及其药学上可接受的盐和(+)(1S,2R,3S)-3-(2-羧甲氧基-4-甲氧基苯基)-1-(3,4-亚甲二氧基苯基)-5-(丙-1-氧基)茚并-2-羧酸及其药学上可接受的盐。本发明还提供了制备这些化合物有用的新型中间体。
• US6080862A
  申请人：——

  公开号：US6080862A

  公开（公告）日：2000-06-27
• US6441173B1
  申请人：——

  公开号：US6441173B1

  公开（公告）日：2002-08-27