4-amino-7-(cis-5'-O-[4-(3-chlorophenyl)-2-oxo-6-spirocyclopropyl-1,3,2-dioxaphosphorinan-2-yl]-2'-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine | 879493-36-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 吡咯并嘧啶核苷和核苷酸
• 英文名称: 4-amino-7-(cis-5'-O-[4-(3-chlorophenyl)-2-oxo-6-spirocyclopropyl-1,3,2-dioxaphosphorinan-2-yl]-2'-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
• 英文别名: (2R,3R,4R,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[[(5R,7S)-7-(3-chlorophenyl)-5-oxo-4,6-dioxa-5lambda5-phosphaspiro[2.5]octan-5-yl]oxymethyl]-3-methyloxolane-3,4-diol；(2R,3R,4R,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[[(5R,7S)-7-(3-chlorophenyl)-5-oxo-4,6-dioxa-5λ5-phosphaspiro[2.5]octan-5-yl]oxymethyl]-3-methyloxolane-3,4-diol
• CAS: 879493-36-4
• 化学式: C₂₃H₂₆ClN₄O₇P
• 分子量: 536.909
• InChiKey: LKUIOETZWTYGHP-AJJVDRGSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  151
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• Novel 2'-c-methyl and 4'c-methyl nucleoside derivatives
  申请人：Erion Mark D.

  公开号：US20090118223A1

  公开（公告）日：2009-05-07

  Novel 2′-C-methyl nucleoside 5′-monophosphate and 4′-C-methyl nucleoside 5′-monophosphate derivatives, stereoisomers, and pharmaceutically acceptable salts or prodrugs thereof, their preparation, and their uses for the treatment of hepatitis C viral infection are described.
• Novel Nucleoside Derivatives
  申请人：Reddy K. Raja

  公开号：US20090131370A1

  公开（公告）日：2009-05-21

  Compounds of Formulae I-XVI, stereoisomers, and pharmaceutically acceptable salts or prodrugs thereof, their preparation, and their uses for the treatment of viral diseases including hepatitis C viral infection, cancer, diabetes, and other diseases are described: formula (I).