氟桂利嗪EP杂质B | 39245-25-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 氟桂利嗪EP杂质B
• 英文名称: Flunarizine impurity B
• 英文别名: 1-[(4-fluorophenyl)-phenylmethyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
• CAS: 39245-25-5
• 化学式: C₂₆H₂₇FN₂
• 分子量: 386.5
• InChiKey: GGYPVQFLPDMNDG-JXMROGBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Antihypoxic agent
  申请人：NAUCHNOISSLEDOVATELSKI CHIMIKOPHARMATZEVTICHEN INSTITUT

  公开号：EP0408782A1

  公开（公告）日：1991-01-23

  The antihypoxic drug of a pharmaceutical composition comprising a combination of 1-cinnamyl-4-(di-p-fluoro-­benzhydryl)-piperazine (flunarizine) and 2-oxo-1-­pyrrolidineacetamide (piracetam) is described. The pharmacological data showed that the combined administration of flunarizine and piracetam in two models of brain hypoxia ( hypobaric and decapitation) lead to mutual potentiation of their antihypoxic effect. Toxicological studies show a strong decrease of the acute toxicity of the combination in comparison with the more toxic component flunarizine. The advantages of the pharmaceutical combination is enhanced cerebro-protective effect and significant reduction of the acute toxicity of flunarizine which might reduce its side effects of extrapyramidal origin.

  描述了由 1-肉桂基-4-(二对氟苯甲基)-哌嗪（氟桂利嗪）和 2-氧代-1-吡咯烷乙酰胺（吡拉西坦）组合而成的药物组合物的抗缺氧药物。 药理学数据显示，在两种脑缺氧模型（低压和断头）中联合使用氟桂利嗪和吡拉西坦，会导致它们的抗缺氧作用相互增强。 毒理学研究表明，与毒性更强的氟桂利嗪相比，该组合药物的急性毒性大大降低。 这种药物组合的优点是增强了脑保护作用，并显著降低了氟桂利嗪的急性毒性，从而可能减少其锥体外系副作用。
• FLUORINE CONTAINING COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Ritter Tobias

  公开号：US20120095217A1

  公开（公告）日：2012-04-19

  Fluorinated compounds and methods of making fluorinated compounds are described herein.
• [EN] FLUORINE CONTAINING COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS FLUORÉS ET LEURS PROCÉDÉS D'UTILISATION
  申请人：HARVARD COLLEGE

  公开号：WO2010081036A2

  公开（公告）日：2010-07-15

  Fluorinated compounds and methods of making fluorinated compounds are described herein.