Salicylaldehyde-4-(2-pyridyl)-3-thiosemicarbazone | 171781-96-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Salicylaldehyde-4-(2-pyridyl)-3-thiosemicarbazone
• 英文别名: salicylaldehyde 2-aminopyridine-N-thiohydrazone；4-(2-pyridyl)-1-salicylaldehyde-3-thiosemicarbazone
• CAS: 171781-96-7
• 化学式: C₁₃H₁₂N₄OS
• 分子量: 272.33
• InChiKey: BKRBIHFYTSXQBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.11
• 重原子数：
  19.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69.54
• 氢给体数：
  3.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  dihydrogen hexachloroplatinate 、 Salicylaldehyde-4-(2-pyridyl)-3-thiosemicarbazone 以 甲醇 、 水 为溶剂， 生成 [Pt(salicylaldehyde-2-aminopyridine-N-thiohydrazone)2Cl2]
  参考文献：
  名称：

  Platinum (IV) thiohydrazide, thiodiamine and thiohydrazone complexes: A spectral, antibacterial and cytotoxic study

  摘要：

  Some platinum (IV) complexes [Pt(L)(2)Cl-2] [where, L = 2-aminopyridine-N-thiohydrazide (L-1), (2-aminopyridine-N-thio)-1,3-propanediamine (L-2), benzaidehyde-2-aminopyridine-N-thiohydrazone (L-3) and salicylaldehyde-2-aminopyrtidine-N-thiohydrazone (L-4)] have been synthesized. The thiohydrazides, thiodiamine and thiohydrazones can exist as thione-thiol tautomer and coordinate as a bidentate N-S ligand. The ligands found to act in monobasic bidentate fashion. Analytical data reveals that metal to ligand stoichiometry is 1:2. The complexes have been characterized by elemental analysis, IR, mass, electronic and H-1 NMR spectroscopic studies. In vitro antibacterial and cytotoxic study have also been carried out for some complexes. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2006.04.038
• 作为产物：
  描述：

  2-氨基吡啶 在 氢氧化钾 、 一水合肼 作用下， 以 甲醇 、 水 为溶剂， 反应 4.75h， 生成 Salicylaldehyde-4-(2-pyridyl)-3-thiosemicarbazone
  参考文献：
  名称：

  Platinum (IV) thiohydrazide, thiodiamine and thiohydrazone complexes: A spectral, antibacterial and cytotoxic study

  摘要：

  Some platinum (IV) complexes [Pt(L)(2)Cl-2] [where, L = 2-aminopyridine-N-thiohydrazide (L-1), (2-aminopyridine-N-thio)-1,3-propanediamine (L-2), benzaidehyde-2-aminopyridine-N-thiohydrazone (L-3) and salicylaldehyde-2-aminopyrtidine-N-thiohydrazone (L-4)] have been synthesized. The thiohydrazides, thiodiamine and thiohydrazones can exist as thione-thiol tautomer and coordinate as a bidentate N-S ligand. The ligands found to act in monobasic bidentate fashion. Analytical data reveals that metal to ligand stoichiometry is 1:2. The complexes have been characterized by elemental analysis, IR, mass, electronic and H-1 NMR spectroscopic studies. In vitro antibacterial and cytotoxic study have also been carried out for some complexes. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2006.04.038

文献信息

• Thermal and spectral studies of palladium(II) complexes
  作者：A. K. Mishra、S. B. Mishra、N. Manav、N. K. Kaushik

  DOI：10.1007/s10973-006-7608-0

  日期：2007.11

  Palladium(II) complexes of type [Pd(L)Cl2] [where L =2-aminopyridine-N-thiohydrazide (L1), (2-aminopyridine-N-thio)-1,3-propanediamine (L2), benzaldehyde 2-aminopyridine-N-thiohydrazone (L3) and salicylaldehyde-2-aminopyridine-N-thiohydrazone (L4)] have been synthesized. The thiohydrazide, thiodiamine and thiohydrazones can exist as thione-thiol tautomer and coordinate as a bidentate N-S ligand. The

  [Pd（L）Cl 2类型]的钯（II）配合物[其中 L = 2-氨基吡啶-N-硫代酰肼（L 1），（2-氨基吡啶-N-硫代）-1,3-丙二胺（L 2）合成了苯甲醛2-氨基吡啶-N-硫hydr（L 3）和水杨醛-2-氨基吡啶-N-硫hydr（L 4）]。硫代肼，硫代二胺和硫代azo可作为硫酮-硫醇互变异构体存在，并作为二齿NS配体配位。发现该配体以双齿方式起作用。
• Structural, theoretical and biological studies on Cu2+ and Co2+ complexes of new thiosemicarbazone ligands
  作者：Fatima A. Adam、Yasmeen G. Abou El-Reash、Eida S. Al-Farraj、Ibrahim A. Abdelwahed、Mohammed M. El-Gamil、Ahmed E. Rashed、A.A. El-Moneim、Gaber M. Abu El-Reash

  DOI：10.1016/j.molstruc.2024.138360

  日期：2024.9

  concentration in solution. Moreover, several biological evaluations were carried out for all six compounds to evaluate their potential use as biological agents, including antioxidant activity using 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging approach, anti-microbial activity against , and , DNA degradation activity, in addition to anticancer activity, along with molecular

  合成了两组由 (HL) 和 (HL) 表示的两个 4-吡啶基缩氨基硫脲衍生物配体的 Cu 和 Co 络合物，并利用不同的分析和光谱技术进行了检查，例如（FT-IR、元素分析、磁性研究） 、PXRD、UV-Vis 和 GCMS-）。研究了两种钴配合物的热稳定性和动力学参数。 H NMR技术用于确认两种配体的结构。使用材料软件通过密度函数理论 (DFT) 计算识别了复合物的拟议几何形状。此外，使用 Multiwfn 软件获得了两种配体的分子中原子量子理论 (QTAIM) 拓扑分析。循环伏安图显示铜离子具有电活性并表现出两个还原波。两种配体的荧光研究表明，由于溶液中 Co 浓度的增加，发射强度直接增加。此外，对所有六种化合物进行了多项生物学评估，以评估它们作为生物制剂的潜在用途，包括使用 2,2'-azino-bis(3-乙基苯并噻唑啉-6-磺酸 (ABTS) 自由基清除方法的抗氧化活性、抗氧化活性、
• Thermodynamic and voltammetric studies of salicylaldehyde-4-(2-pyridyl)-3-thiosemicarbazone
  作者：I. S. Shehatta、A. M. Hassanein、E. M. Mabrouk

  DOI：10.1007/bf00811004

  日期：——

  UV spectra, de polarograms, cyclic voltammetry and coulometry measurements of salicylaldehyde-4-(2-pyridyl)-3-thiosemicarbazone (H2SPT) were recorded in Britton-Robinson buffer solutions of pH 2-12. The dissociation constants of H2SPT evaluated spectrophotometrically and potentiometrically in a 5% (v/v) DMF-water mixture are concordant. The dc-polarograms in solutions of pH < 8.5 exhibit a single 4-electron diffusion-controlled polarographic wave, whereas in solutions of pH > 8.5 two waves are observed. The cyclic voltammograms give a single cathodic peak in acidic and neutral solutions, whereas two cathodic peaks can be identified in alkaline ones. An electrode mechanism is proposed and discussed. The effect of temperature on the dissociation constants and the polarographic data was also investigated; the corresponding thermodynamic parameters were derived and are discussed.
• Synthesis, Spectral and Magnetic Investigation of 4-(2-pyridyl)-1-salicylaldehyde-3-thiosemicarbazone
  作者：Usama El-Ayaan、Gaber Abu El-Reash、Peter Weinberger、Wolfgang Linert

  DOI：10.1080/00945710009351867

  日期：2000.10.1