(2R)-2-[4-[(4-Methyl-1-piperazinyl)carbonyl]phenoxy]-3,3-diethyl-N-[(1S)-1-[3,4-(methylenedioxy)phenyl]butyl]-4-oxo-1-azetidinecarboxamide | 221352-20-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (2R)-2-[4-[(4-Methyl-1-piperazinyl)carbonyl]phenoxy]-3,3-diethyl-N-[(1S)-1-[3,4-(methylenedioxy)phenyl]butyl]-4-oxo-1-azetidinecarboxamide
• 英文别名: (2R)-N-[(1S)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-(4-methylpiperazine-1-carbonyl)phenoxy]-4-oxoazetidine-1-carboxamide
• CAS: 221352-20-1
• 化学式: C₃₁H₄₀N₄O₆
• 分子量: 564.7
• InChiKey: ZSDCIRYNTCVTMF-PWUYWRBVSA-N

物化性质

• 密度：
  1.227±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Use of polyalkylamine polymers in controlled release devices
  申请人：——

  公开号：US20020160047A1

  公开（公告）日：2002-10-31

  The invention provides a method and device for administering an amine drug, such as [S—(R,S)]-2-[4-[[(4-methyl)piperazin-1-yl]carbonyl]phenoxy]-3,3-diethyl-N-[1-(3,4-methylenedioxyphenyl)butyl]-4-oxo-1-azetidinecarboxamide), in a sustained release dosage form. The invention includes a pharmaceutical composition and dosage form containing a polyalkylamine polymer and an amine drug. The polyalkylamine polymer is a hydrogel that forms hydrated particles when exposed to an aqueous environment. When mixed with the amine drug in the core of a coated tablet, the polyalkylamine polymer controls the release of the amine drug into an aqueous environment of use. The hydrated particles of the polymer together with the amine drug are released from the tablet core through plural apertures in the surrounding coat.

  本发明提供了一种施用胺类药物的方法和装置，如[S-(R,S)]-2-[4-[[(4-甲基)哌嗪-1-基&rsqb；羰基]苯氧基]-3,3-二乙基-N-[1-(3,4-亚甲基二氧苯基)丁基]-4-氧代-1-氮杂环丁烷甲酰胺)的缓释剂型。本发明包括一种含有聚烷基胺聚合物和胺类药物的药物组合物和剂型。聚烷基胺聚合物是一种水凝胶，暴露在水环境中会形成水合颗粒。当聚烷基胺聚合物与胺类药物混合在包衣片剂的片芯中时，聚烷基胺聚合物可控制胺类药物在水环境中的释放。聚合物的水合颗粒与胺类药物一起通过周围包衣上的多个小孔从片芯中释放出来。
• US6649187B2
  申请人：——

  公开号：US6649187B2

  公开（公告）日：2003-11-18
• [EN] USE OF POLYALKYLAMINE POLYMERS IN CONTROLLED RELEASE DEVICES<br/>[FR] UTILISATION DE POLYMERES DE POLYALKYLAMINE DANS DES DISPOSITIFS A LIBERATION REGULEE
  申请人：BRISTOL MYERS SQUIBB PHARMA CO

  公开号：WO2002066015A1

  公开（公告）日：2002-08-29

  The invention provides a method and device for administering an amine drug, such as [S-(R,S)]-2-[4-[[(4-methyl)piperazin-1-yl]carbonyl]phenoxy]-3,3-diethyl-N-[1-(3,4-methylenedioxyphenyl)butyl]-4-oxo-1-azetidinecarboxamide), in a sustained release dosage form. The invention includes a pharmaceutical composition and dosage form containing a polyalkylamine polymer and an amine drug. The polyalkylamine polymer is a hydrogel that forms hydrated particles when exposed to an aqueous environment. When mixed with the amine drug in the core of a coated tablet, the polyalkylamine polymer controls the release of the amine drug into an aqueous environment of use. The hydrated particles of the polymer together with the amine drug are released from the tablet core through plural apertures in the surrounding coat.