3-Methoxypyridine-2-sulfonamide | 1566809-26-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Methoxypyridine-2-sulfonamide
• CAS: 1566809-26-4
• 化学式: C₆H₈N₂O₃S
• 分子量: 188.21
• InChiKey: URTFTODLVLJQPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  90.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Antitumor Agent
  申请人：Taiho Pharmaceutical Co., Ltd

  公开号：US20200405697A1

  公开（公告）日：2020-12-31

  The present invention provides a method of enhancing an antitumor effect by a compound strongly inhibiting ribonucleotide reductase (RNR) or a salt thereof. A combination formulation involving combined administration of a sulfonamide compound represented by Formula (I) [In the formula, X 1 represents an oxygen atom or the like; X 2 represents an oxygen atom; X 3 represents —NH—; X 4 represents a hydrogen atom or the like; R 1 represents —C(R 11 ) (R 12 )— or the like; R 11 and R 12 are the same or different and each represents a hydrogen atom or the like; R 2 represents an optionally substituted C6-C14 aromatic hydrocarbon group or the like; R 3 represents an optionally substituted C6-C14 aromatic hydrocarbon group or the like; R 4 represents a hydrogen atom or the like] or a salt thereof, having RNR inhibitory activity, and other antitumor agent(s).